Evidence map›Paper›PMID 20510282›Full record

SynthesisThe Lancet. Infectious diseases2010

Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis.

Elizabeth A Reddy, Andrea V Shaw, John A Crump

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Lancet. Infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 399 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
399citing papers in PubMed, 18 pooled it
18.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

399 citing papers in PubMed, 18 syntheses or guidelines pooled it, 652 citations in OpenAlex.

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  10. A Systematic Review on Antimicrobial Resistance amongThe American journal of tropical medicine and hygiene · 2020
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339 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Elizabeth A ReddyDepartment of Medicine, Duke University Medical Center, Durham, NC 27710, USA. reddy009@mc.duke.edu <reddy009@mc.duke.edu>
Andrea V Shaw
John A Crump
Duke Medical Center · USChristian Medical College & Hospital · IN

Funding

Viral Sequencing CoreU19AI067854 · NIAID · DUKE UNIVERSITY · PI BHARDWAJ, NINA · 2006 to 2011
$290.5M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
HIV/AIDS Clinical Trials UnitU01AI069484 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2007 to 2011
$14.6M
HIV/AIDS Clinical Trials UnitUM1AI069484 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2012 to 2014
$5.6M
International Clinical Trials UnitU01AI062563 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2004 to 2007
$4.0M
AIDS International Training and Research ProgramD43TW006732 · FIC · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2004 to 2012
$2.7M
FIC NIH HHS D43 TW006732NIAID NIH HHS P30 AI064518NIAID NIH HHS P30 AI 64518NIAID NIH HHS U01 AI062563NIAID NIH HHS U01 AI069484NIAID NIH HHS U01 AI069484-01NIAID NIH HHS U19 AI067854NIAID NIH HHS UM1 AI069484
6 · The paper itself

Abstract

Data on the prevalence and causes of community-acquired bloodstream infections in Africa are scarce. We searched three databases for studies that prospectively studied patients admitted to hospital with at least a blood culture, and found 22 eligible studies describing 58 296 patients, of whom 2051 (13.5%) of 15 166 adults and 3527 (8.2%) of 43 130 children had bloodstream infections. 1643 (29.1%) non-malaria bloodstream infections were due to Salmonella enterica (58.4% of these non-typhoidal Salmonella), the most prevalent isolate overall and in adults, and 1031 (18.3% overall) were due to Streptococcus pneumoniae, the most common isolate in children. Other common isolates included Staphylococcus aureus (531 infections; 9.5%) and Escherichia coli (412; 7.3%). Mycobacterium tuberculosis complex accounted for 166 (30.7%) of 539 isolates in seven studies that used mycobacterial culture techniques. HIV infection was associated with any bloodstream infection, particularly with S enterica and M tuberculosis complex bacteraemia. Where recorded, patients with bloodstream infections had an in-hospital case fatality of 18.1%. Our results show that bloodstream infections are common and associated with high mortality. Improved clinical microbiology services and reassessment of empirical treatment guidelines that account for the epidemiology of bloodstream infections might contribute to better outcomes.

Indexed as

AdultAfricaAnimalsBacteremiaBacteriaChildChild, PreschoolCommunity-Acquired InfectionsHumansPrevalenceYoung Adult

Identifiers

PMID20510282
PMCPMC3168734
OpenAlexW2090839261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.