Evidence map›Paper›PMID 20510236›Full record

ReviewRheumatic diseases clinics of North America2010

Cell-cell interactions in rheumatoid arthritis synovium.

David A Fox, Alison Gizinski, Rachel Morgan, Steven K Lundy

Open access · greenAbstract readReview
In one paragraph

Review in Rheumatic diseases clinics of North America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Immunosuppression in Rheumatologic and Auto-immune Disease.Handbook of experimental pharmacology · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Angiogenic and Arthritogenic Properties of the Soluble Form of CD13.Journal of immunology (Baltimore, Md. : 1950) · 2019
    Article
  17. Inhibition of MMPs and ADAM/ADAMTS.Biochemical pharmacology · 2019
    Review
  18. Review
  19. Review
  20. The role of the JAK/STAT signal pathway in rheumatoid arthritis.Therapeutic advances in musculoskeletal disease · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

David A FoxDivision of Rheumatology and Rheumatic Diseases Research Core Center, 3918 Taubman Center, 1500 East Medical Center Drive, The University of Michigan, Ann Arbor, MI 48109, USA. dfox@umich.edu <dfox@umich.edu>
Alison Gizinski
Rachel Morgan
Steven K Lundy
University of Michigan–Ann Arbor · US

Funding

Vector CoreP30AR048310 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROESSLER, BLAKE J · 2001 to 2010
$5.9M
UNIQUE SURFACE STRUCTURES ON SYNOVIAL CELLSR01AR038477 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FOX, DAVID ALAN · 1991 to 2011
$2.9M
Regulation of Antigen-Specific T Cells and Arthrites Inflammation by B CellsK01AR053846 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUNDY, STEVEN K. · 2007 to 2011
$558k
NIAMS NIH HHS K01 AR053846NIAMS NIH HHS NIH RO-1 AR38477NIAMS NIH HHS P30 AR048310NIAMS NIH HHS R01 AR038477
6 · The paper itself

Abstract

Understanding the pathogenesis of joint inflammation and destruction in rheumatoid arthritis involves dissection of the cellular and molecular interactions that occur in synovial tissue. Development of effective targeted therapies has been based on progress in achieving such insights. Safer and more specific approaches to treatment could flow from discovery of cell-cell interaction pathways that are specific to inflammation of the joint and less important in the defense against systemic infection. This article highlights selected cell-cell interactions in rheumatoid arthritis synovium that may be worthy of evaluation as future therapeutic targets.

Indexed as

AnimalsAntigen-Presenting CellsArthritis, RheumatoidB-LymphocytesCell CommunicationEndothelial CellsFibroblastsHumansSynovial MembraneT-Lymphocytes

Identifiers

PMID20510236
PMCPMC2879397
OpenAlexW2054992861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.