ArticleBMC infectious diseases2010
High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children.
Article in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An Appraisal of the Clinical Features of Pediatric Enteric Fever: Systematic Review and Meta-analysis of the Age-Stratified Disease Occurrence.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam.PLoS neglected tropical diseases · 2011Trial
- Performance of mechanically sheared DNA in multiplexed Oxford Nanopore sequencing forMicrobial genomics · 2026Article
- Leveraging illumina iSeq100 for whole genome sequencing of Salmonella Typhi for a resource-limited setting.Scientific reports · 2025Article
- The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi.Communications biology · 2024Article
- Typhoid fever.Nature reviews. Disease primers · 2023Review
- Genomic Investigation ofMicroorganisms · 2023Article
- Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework.The Journal of infectious diseases · 2021Review
- Susceptibility pattern of Salmonella enterica against commonly prescribed antibiotics, to febrile-pediatric cases, in low-income countries.BMC pediatrics · 2021Article
- Gallbladder carriage generates genetic variation and genome degradation in Salmonella Typhi.PLoS pathogens · 2020Article
- Persistent circulation of a fluoroquinolone-resistant Salmonella enterica Typhi clone in the Indian subcontinent.The Journal of antimicrobial chemotherapy · 2020Article
- Population structure and transmission modes of indigenous typhoid in Taiwan.BMC medical genomics · 2019Article
- Article
- Non-specificity of sequence characterised amplified region as an alternative molecular epidemiology marker for the identification of Salmonella enterica subspecies enterica serovar Typhi.BMC research notes · 2018Article
- Antimicrobial Resistance in Invasive Bacterial Infections in Hospitalized Children, Cambodia, 2007-2016.Emerging infectious diseases · 2018Article
- Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.PLoS neglected tropical diseases · 2018Article
- Dual-strain genital herpes simplex virus type 2 (HSV-2) infection in the US, Peru, and 8 countries in sub-Saharan Africa: A nested cross-sectional viral genotyping study.PLoS medicine · 2017Article
- Characterization of antimicrobial resistance markers & their stability inThe Indian journal of medical research · 2017Article
- The impact of migration and antimicrobial resistance on the transmission dynamics of typhoid fever in Kathmandu, Nepal: A mathematical modelling study.PLoS neglected tropical diseases · 2017Article
- PathoBacTyper: A Web Server for Pathogenic Bacteria Identification and Molecular Genotyping.Frontiers in microbiology · 2017Article
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14 authors.
Funding
Abstract
backgroundSalmonella Typhi (S. Typhi) causes typhoid fever, which remains an important public health issue in many developing countries. Kathmandu, the capital of Nepal, is an area of high incidence and the pediatric population appears to be at high risk of exposure and infection.
methodsWe recently defined the population structure of S. Typhi, using new sequencing technologies to identify nearly 2,000 single nucleotide polymorphisms (SNPs) that can be used as unequivocal phylogenetic markers. Here we have used the GoldenGate (Illumina) platform to simultaneously type 1,500 of these SNPs in 62 S. Typhi isolates causing severe typhoid in children admitted to Patan Hospital in Kathmandu.
resultsEight distinct S. Typhi haplotypes were identified during the 20-month study period, with 68% of isolates belonging to a subclone of the previously defined H58 S. Typhi. This subclone was closely associated with resistance to nalidixic acid, with all isolates from this group demonstrating a resistant phenotype and harbouring the same resistance-associated SNP in GyrA (Phe83). A secondary clone, comprising 19% of isolates, was observed only during the second half of the study.
conclusionsOur data demonstrate the utility of SNP typing for monitoring bacterial populations over a defined period in a single endemic setting. We provide evidence for genotype introduction and define a nalidixic acid resistant subclone of S. Typhi, which appears to be the dominant cause of severe pediatric typhoid in Kathmandu during the study period.
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