ArticleAngewandte Chemie (International ed. in English)2010
Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulin.
Article in Angewandte Chemie (International ed. in English), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed, 73 citations in OpenAlex.
- Oxidative Folding of a Two-Chain Protein Having Three Interchain Disulfide Bonds. Synthesis of Bromelain Inhibitor VI Through Native Chain Assembly.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Rapid synthesis of glycosylated insulins by flow-based peptide synthesis.Chemical science · 2025Article
- Synthetic studies of the mutant proinsulin syndrome demonstrate correlation between folding efficiency and age of diabetes onset.International journal of peptide research and therapeutics · 2025Article
- A Chemical Counterpart to the Resolution Step of Nature's Intein-Mediated Protein Splicing.ACS chemical biology · 2024Article
- Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity.Communications chemistry · 2023Article
- Synthesis of ubiquitinated proteins for biochemical and functional analysis.Chemical science · 2023Review
- Structural Lessons From the Mutant Proinsulin Syndrome.Frontiers in endocrinology · 2021Review
- Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- General lack of structural characterization of chemically synthesized long peptides.Protein science : a publication of the Protein Society · 2019Review
- Synthesis of hydrophobic insulin-based peptides using a helping hand strategy.Organic & biomolecular chemistry · 2019Article
- Novel protein science enabled by total chemical synthesis.Protein science : a publication of the Protein Society · 2019Review
- Facile folding of insulin variants bearing a prosthetic C-peptide prepared by α-ketoacid-hydroxylamine (KAHA) ligation.Chemical science · 2018Article
- Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases.Chemical science · 2018Article
- Chemically Precise Glycoengineering Improves Human Insulin.ACS chemical biology · 2018Article
- Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Pursuit of a perfect insulin.Nature reviews. Drug discovery · 2016Review
- Efficient Total Chemical Synthesis of (13) C=(18) O Isotopomers of Human Insulin for Isotope-Edited FTIR.Chembiochem : a European journal of chemical biology · 2016Article
- Fully convergent chemical synthesis of ester insulin: determination of the high resolution X-ray structure by racemic protein crystallography.Journal of the American Chemical Society · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.