Evidence map›Paper›PMID 20509010›Full record

ReviewCurrent hypertension reports2010

New therapeutic approaches to resistant hypertension.

Markus P Schlaich, Henry Krum, Murray D Esler

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01932450 (A Randomized, Open-label Study Investigating the Effect of Bilateral Renal Artery Sympathetic Denervation by Catheter-based Radiofrequency Ablation on Blood Pressure and Disease Progression in Autosomal Dominant Polycystic Kidney Disease), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01932450 phase2unknown statusnot on this mapstarted 2013, after this paper: background citation

A Randomized, Open-label Study Investigating the Effect of Bilateral Renal Artery Sympathetic Denervation by Catheter-based Radiofrequency Ablation on Blood Pressure and Disease Progression in Autosomal Dominant Polycystic Kidney Disease

TypeinterventionalSponsorMei changlinRan2013 to 2015Enrolled100ConditionsAutosomal Dominant Polycystic Kidney Disease, HypertensionArmsrenal sympathetic denervation, antihypertensive drugs
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Postmenopausal hypertension: role of the sympathetic nervous system in an animal model.American journal of physiology. Regulatory, integrative and comparative physiology · 2014
    Article
  2. Review
  3. Review
  4. Resistant hypertension workup and approach to treatment.International journal of hypertension · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Markus P SchlaichNeurovascular Hypertension & Kidney Disease Laboratory, Baker IDI Heart & Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008, Australia. markus.schlaich@bakeridi.edu.au
Henry Krum
Murray D Esler

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistant hypertension is a common and growing clinical problem characterized by failure to achieve target blood pressure levels despite adequate use of at least three antihypertensive agents. Although numerous safe and effective pharmacologic therapies are available to treat elevated blood pressure, novel therapeutic approaches are warranted to improve the management and prognosis of patients with resistant hypertension. In this context, several lines of research have generated promising results based on both novel pharmacologic and device-based approaches that may more effectively treat resistant hypertension and its adverse consequences in the future.

Indexed as

Treatment FailureAntihypertensive AgentsBaroreflexEndothelin Receptor AntagonistsHumansHypertensionHypertension, RenovascularKidneyPrognosisRenin-Angiotensin SystemSympathetic Nervous SystemAntihypertensive AgentsEndothelin Receptor Antagonists

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.