ReviewJournal of inherited metabolic disease2011
Cobalamin status in children.
Review in Journal of inherited metabolic disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Association between vitamin B12 intake and EURRECA's prioritized biomarkers of vitamin B12 in young populations: a systematic review.Public health nutrition · 2013Pooled it
- Trial
- Vitamin B12 in early childhood: a phenotype-guided approach to deficiency and unexpectedly elevated concentrations.European journal of pediatrics · 2026Review
- The Benefit of Detecting Reduced Intracellular B12 Activity through Newborn Screening Remains Unclear.International journal of neonatal screening · 2024Article
- Risk Assessment of Micronutrients Deficiency in Vegetarian or Vegan Children: Not So Obvious.Nutrients · 2023Review
- Folate - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
- Vitamin BFood & nutrition research · 2023Article
- Dietary Vitamin B Complex: Orchestration in Human Nutrition throughout Life with Sex Differences.Nutrients · 2022Review
- Serial Measurement of Serum Pancreatic Lipase Immunoreactivity, Feline Trypsin-like Immunoreactivity, and Cobalamin Concentrations in Kittens.Veterinary sciences · 2022Article
- Prevalence of serum cobalamin and folate deficiency among children aged 6-59 months: A hospital-based cross-sectional study from Northern India.Journal of family medicine and primary care · 2022Article
- Serum folate and vitamin B12 status in young Brazilian children.Public health nutrition · 2019Article
- The Revised D-A-CH-Reference Values for the Intake of Vitamin BMolecular nutrition & food research · 2019Article
- Maternal and infant vitamin B12 status and development.Pediatric research · 2018Article
- The association between serum vitamin BNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Article
- An infant and mother with severe BEuropean journal of clinical nutrition · 2017Article
- Vitamin BEuropean journal of nutrition · 2017Article
- Vitamin Status among Breastfed Infants in Bhaktapur, Nepal.Nutrients · 2016Article
- Genetic and environmental factors associated with vitamin B12 status in Amazonian children.Public health nutrition · 2015Article
- Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12).EFSA journal. European Food Safety Authority · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cobalamin and the metabolic markers methylmalonic acid and total homocysteine undergo marked changes during childhood. In breastfed infants a metabolic profile indicative of cobalamin deficiency is common. Symptoms of cobalamin deficiency in children differ with age, presenting a continuum from subtle developmental delay to life-threatening clinical conditions. The symptoms may be difficult to detect, particularly in infants, and there tends to be a diagnostic delay of several months in this age group. Several reports show that even moderate deficiency in children may be harmful, and long-term consequences of neurological deterioration may persist after cobalamin deficiency has been treated. Given the crucial role of cobalamin for normal growth and development, possible widespread infantile deficiency needs attention. Cobalamin deficiency should be considered a differential diagnosis in children with subtle symptoms, and strategies to prevent cobalamin deficiency in mothers and children should be addressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.