ArticleFrontiers in neural circuits2010
A Signal Processing Analysis of Purkinje Cells in vitro.
Article in Frontiers in neural circuits, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Review
- Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of CaCells · 2021Review
- Power Spectral Density Analysis of Purkinje Cell Tonic and Burst Firing Patterns From a Rat Model of Ataxia and Riluzole Treated.Basic and clinical neuroscience · 2017Article
- The 40-year history of modeling active dendrites in cerebellar Purkinje cells: emergence of the first single cell "community model".Frontiers in computational neuroscience · 2015Review
- Tuning photochromic ion channel blockers.ACS chemical neuroscience · 2011Article
- Signals and circuits in the purkinje neuron.Frontiers in neural circuits · 2011Article
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Authors and funding
4 authors.
Funding
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Abstract
Cerebellar Purkinje cells in vitro fire recurrent sequences of Sodium and Calcium spikes. Here, we analyze the Purkinje cell using harmonic analysis, and our experiments reveal that its output signal is comprised of three distinct frequency bands, which are combined using Amplitude and Frequency Modulation (AM/FM). We find that the three characteristic frequencies - Sodium, Calcium and Switching - occur in various combinations in all waveforms observed using whole-cell current clamp recordings. We found that the Calcium frequency can display a frequency doubling of its frequency mode, and the Switching frequency can act as a possible generator of pauses that are typically seen in Purkinje output recordings. Using a reversibly photo-switchable kainate receptor agonist, we demonstrate the external modulation of the Calcium and Switching frequencies. These experiments and Fourier analysis suggest that the Purkinje cell can be understood as a harmonic signal oscillator, enabling a higher level of interpretation of Purkinje signaling based on modern signal processing techniques.
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