ArticleEMBO reports2010
Nucleosome occupancy landscape and dynamics at mouse recombination hotspots.
Article in EMBO reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.Genome biology · 2022Article
- Nucleosome-induced homology recognition in chromatin.Journal of the Royal Society, Interface · 2021Article
- Contributions of Flow Cytometry to the Molecular Study of Spermatogenesis in Mammals.International journal of molecular sciences · 2021Review
- Epigenetic Marks and Variation of Sequence-Based Information Along Genomic Regions Are Predictive of Recombination Hot/Cold Spots inFrontiers in genetics · 2021Article
- Article
- BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis.PLoS genetics · 2018Article
- Meiotic crossovers are associated with open chromatin and enriched with Stowaway transposons in potato.Genome biology · 2017Article
- Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice.Cell cycle (Georgetown, Tex.) · 2017Article
- Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.Molecular and cellular biology · 2017Article
- Article
- Multispecies Purification of Testicular Germ Cells.Biology of reproduction · 2016Article
- Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing.Scientific reports · 2016Article
- Recombination spot identification Based on gapped k-mers.Scientific reports · 2016Article
- RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development.Molecular and cellular biology · 2015Article
- Optimized flow cytometry isolation of murine spermatocytes.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2014Article
- PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration.Genome research · 2014Article
- Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin.Nucleic acids research · 2014Article
- The Drosophila early ovarian transcriptome provides insight to the molecular causes of recombination rate variation across genomes.BMC genomics · 2013Article
- Contrasted patterns of crossover and non-crossover at Arabidopsis thaliana meiotic recombination hotspots.PLoS genetics · 2013Article
- Deregulated chromatin remodeling in the pathobiology of brain tumors.Neuromolecular medicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
During meiosis, paternal and maternal homologous chromosomes recombine at specific recombination sites named hotspots. What renders 2% of the mammalian genomes permissive to meiotic recombination by allowing Spo11 endonuclease to initiate double-strand breaks is largely unknown. Work in yeast has shown that chromatin accessibility seems to be important for this activity. Here, we define nucleosome profiles and dynamics at four mouse recombination hotspots by purifying highly enriched fractions of meiotic cells. We found that nucleosome occupancy is generally stable during meiosis progression. Interestingly, the cores of recombination hotspots have largely open chromatin structure, and the localization of the few nucleosomes present in these cores correlates precisely with the crossover-free zones in recombinogenic domains. Collectively, these high-resolution studies suggest that nucleosome occupancy seems to direct, at least in part, how meiotic recombination events are processed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.