ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2010
Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.
Review in American journal of physiology. Gastrointestinal and liver physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?Pharmaceuticals (Basel, Switzerland) · 2024Review
- Article
- Application and prospects of high-throughput screening forWorld journal of stem cells · 2022Review
- Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.The Biochemical journal · 2019Article
- Article
- Wnt signaling and polarity in freshwater sponges.BMC evolutionary biology · 2018Article
- Determination of the relationship between doxorubicin resistance and Wnt signaling pathway in HeLa and K562 cell lines.EXCLI journal · 2018Article
- N-substituted phenylbenzamides of the niclosamide chemotype attenuate obesity related changes in high fat diet fed mice.PloS one · 2018Article
- Reversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Niclosamide is a Negative Allosteric Modulator of Group I Metabotropic Glutamate Receptors: Implications for Neuropathic Pain.Pharmaceutical research · 2016Article
- S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction.Cancers · 2016Review
- WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.Oncogene · 2015Article
- Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review.World journal of experimental medicine · 2015Review
- Structural dynamics and inhibitor searching for Wnt-4 protein using comparative computational studies.Drug design, development and therapy · 2015Article
- Effect of niclosamide on basal-like breast cancers.Molecular cancer therapeutics · 2014Article
- Has discovery-based cancer research been a bust?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2013Article
- Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer.Oncology letters · 2013Article
- PI3 Kinase regulation of neural regeneration and muscle hypertrophy after spinal cord injury.Molecular biology reports · 2012Review
- Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production.Blood cancer journal · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Wnt proteins play major roles in development and differentiation, and abnormalities in their regulation are believed to contribute to the formation of many cancers, including colorectal malignancies. As a result, there has been an interest in identifying small molecule inhibitors of Wnt signaling as tool compounds for research or as precursors to new generations of anticancer drugs. Advancements in robotic technology along with reductions in the costs of equipment, chemical libraries, and information handling have made high-throughput drug discovery programs possible in an academic setting. In this minireview we discuss the most plausible protein targets for inhibiting Wnt signaling in colon cancer therapy, list small molecule Wnt inhibitors that have been identified through recent drug discovery efforts, and provide our laboratory's strategy for identifying novel Wnt signaling antagonists using high-throughput screening. In particular, we summarize the results of a screen of over 1,200 drug and druglike compounds we recently completed in which niclosamide was identified as a Wnt pathway antagonist.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.