ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2010
Enhancing effects of flavored nutritive stimuli on cortical swallowing network activity.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Hinoki Cypress Aroma Facilitates Swallowing via Premotor and Hypothalamic Down-modulation: A Randomized Within-subject Crossover fMRI Study.Dysphagia · 2026Trial
- Improved olfactory function following high-frequency transcutaneous auricular vagal nerve stimulation in post-COVID-19 patients with olfactory dysfunction.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Food-Consistency/Texture-Specific Pharyngeal Dystonia: A Novel Form of Focal Task-Specific Dystonia.Movement disorders clinical practice · 2025Article
- Cerebral hemodynamics and functional connectivity changes in stroke patients with dysphagia under acidic taste stimulation: a preliminary study.Frontiers in neurology · 2025Article
- Comparing Taste Perception Across Modalities in Healthy Adults: Liquids Versus Dissolvable Taste Strips.Dysphagia · 2024Article
- The importance of taste on swallowing function.Frontiers in nutrition · 2024Review
- Brain activity associated with taste stimulation: A mechanism for neuroplastic change?Brain and behavior · 2023Article
- Neural basis of dysphagia in stroke: A systematic review and meta-analysis.Frontiers in human neuroscience · 2023Review
- Effects of Carbonated Thickened Drinks on Pharyngeal Swallowing with a Flexible Endoscopic Evaluation of Swallowing in Older Patients with Oropharyngeal Dysphagia.Healthcare (Basel, Switzerland) · 2022Article
- Molecular and Neural Mechanism of Dysphagia Due to Cancer.International journal of molecular sciences · 2021Review
- Targeting Chemosensory Ion Channels in Peripheral Swallowing-Related Regions for the Management of Oropharyngeal Dysphagia.International journal of molecular sciences · 2020Review
- Genetic Taster Status as a Mediator of Neural Activity and Swallowing Mechanics in Healthy Adults.Frontiers in neuroscience · 2019Article
- Saliva Production and Enjoyment of Real-Food Flavors in People with and Without Dysphagia and/or Xerostomia.Dysphagia · 2018Article
- Autobiography of James S. Hyde.Applied magnetic resonance · 2017Article
- Article
- Sour taste increases swallowing and prolongs hemodynamic responses in the cortical swallowing network.Journal of neurophysiology · 2016Article
- Compensatory recombination phenomena of neurological functions in central dysphagia patients.Neural regeneration research · 2015Article
- Using sensory properties of food to trigger swallowing: a review.Critical reviews in food science and nutrition · 2015Review
- Esophageal reflexes modulate frontoparietal response in neonates: Novel application of concurrent NIRS and provocative esophageal manometry.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Effect of carbonated beverages on pharyngeal swallowing in young individuals and elderly inpatients.Dysphagia · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A better understanding of the central control of the physiology of deglutition is necessary for devising interventions aimed at correcting pathophysiological conditions of swallowing. Positive modulation of the cortical swallowing network can have clinical ramifications in dysphagia due to central nervous system deficits. Our aim was to determine the effect of nutritive sensory input on the cortical swallowing network. In 14 healthy right-handed volunteers, we utilized a paradigm-driven protocol to quantify the number of activated voxels and their signal intensity within the left hemispheric cortical swallowing network by high-resolution functional MRI (fMRI) during five different swallowing conditions. Swallowing conditions included a dry swallow (saliva) and natural water-, lemon-, popcorn-, and chocolate-flavored liquid swallows. Each flavored liquid was presented simultaneously by its image, scent, and taste in random order and tested over three runs. fMRIs were analyzed in a blinded fashion. Average fMRI blood oxygenation level-dependent signal intensity and number of activated voxels during swallowing concurrent with nutritive gustatory, olfactory, and visual stimulations were significantly increased compared with dry/natural water swallows throughout the cortical swallowing network (P < 0.001 and P < 0.05, respectively). Subregion analysis showed the increased activity for flavored liquids in prefrontal, cingulate gyrus, and sensory/motor cortex, but not in precuneus and insula. Concurrent gustatory, olfactory, and visual nutritive stimulation enhances the activity of the cortical swallowing network. This finding may have clinical implications in management of swallowing disorders due to cortical lesions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.