ArticleGenome research2010
A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes.
Article in Genome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide epistasis study highlights genetic interactions influencing severity of COVID-19.European journal of epidemiology · 2023Pooled it
- Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis.Scientific reports · 2016Pooled it
- Genetic polymorphisms associated with metabolic dysfunction-associated steatotic liver disease and cardiometabolic risk susceptibility in the Chinese Han population.Human genomics · 2025Article
- Interactomic exploration of LRRC8A in volume-regulated anion channels.Cell death discovery · 2024Article
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- Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer.Genome biology · 2023Article
- In individuals with Williams syndrome, dysregulation of methylation in non-coding regions of neuronal and oligodendrocyte DNA is associated with pathology and cortical development.Molecular psychiatry · 2023Article
- Polymorphisms inGenes · 2022Article
- How Variation in Risk Allele Output and Gene Interactions Shape the Genetic Architecture of Schizophrenia.Genes · 2022Article
- Concurrent outcomes from multiple approaches of epistasis analysis for human body mass index associated loci provide insights into obesity biology.Scientific reports · 2022Article
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- Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease.Communications biology · 2022Article
- Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson's disease.Translational neuroscience · 2022Article
- Scrapie-Responsive Gene 1 Promotes Chondrogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells via Wnt5a.Stem cells international · 2022Article
- Protein Receptors Evolved from Homologous Cohesion Modules That Self-Associated and Are Encoded by Interactive Networked Genes.Life (Basel, Switzerland) · 2021Article
- A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma.Scientific reports · 2021Article
- Network Modeling in Biology: Statistical Methods for Gene and Brain Networks.Statistical science : a review journal of the Institute of Mathematical Statistics · 2021Article
- Cost-Effective Mapping of Genetic Interactions in Mammalian Cells.Frontiers in genetics · 2021Article
- Analysis of Major Depression Risk Genes Reveals Evolutionary Conservation, Shared Phenotypes, and Extensive Genetic Interactions.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Using radiation hybrid genotyping data, 99% of all possible gene pairs across the mammalian genome were tested for interactions based on co-retention frequencies higher (attraction) or lower (repulsion) than chance. Gene interaction networks constructed from six independent data sets overlapped strongly. Combining the data sets resulted in a network of more than seven million interactions, almost all attractive. This network overlapped with protein-protein interaction networks on multiple measures and also confirmed the relationship between essentiality and centrality. In contrast to other biological networks, the radiation hybrid network did not show a scale-free distribution of connectivity but was Gaussian-like, suggesting a closer approach to saturation. The radiation hybrid (RH) network constitutes a platform for understanding the systems biology of the mammalian cell.
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Registered trials
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