ArticlePlant physiology2010
Activation of plant immune responses by a gain-of-function mutation in an atypical receptor-like kinase.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 82 citations in OpenAlex.
- Article
- Protein Phosphatase 5 Promotes SUMM2-Mediated Immunity by Facilitating Its Protein Accumulation.Plants (Basel, Switzerland) · 2026Article
- Plant Immunity: At the Crossroads of Pathogen Perception and Defense Response.Plants (Basel, Switzerland) · 2024Review
- LAZARUS 1 functions as a positive regulator of plant immunity and systemic acquired resistance.Frontiers in plant science · 2024Article
- RLPredictiOme, a Machine Learning-Derived Method for High-Throughput Prediction of Plant Receptor-like Proteins, Reveals Novel Classes of Transmembrane Receptors.International journal of molecular sciences · 2022Article
- Opposing effects of MYZUS PERSICAE-INDUCED LIPASE 1 and jasmonic acid influence the outcome of Arabidopsis thaliana-Fusarium graminearum interaction.Molecular plant pathology · 2022Article
- Article
- Specific Changes inMetabolites · 2022Article
- Analysis of genome variants in dwarf soybean lines obtained in F6 derived from cross of normal parents (cultivated and wild soybean).Genomics & informatics · 2021Article
- Leaf Lipid Alterations in Response to Heat Stress ofPlants (Basel, Switzerland) · 2020Article
- Analysis of QTL DM4.1 for Downy Mildew Resistance in Cucumber Reveals Multiple subQTL: A NovelFrontiers in plant science · 2020Article
- Phaeophyceaean (Brown Algal) Extracts Activate Plant Defense Systems inFrontiers in plant science · 2020Article
- MKK6 Functions in Two Parallel MAP Kinase Cascades in Immune Signaling.Plant physiology · 2018Article
- Autoimmunity in plants.Planta · 2018Review
- Transcriptomic analysis reveals vacuolar NaBMC plant biology · 2018Article
- Comparative Transcriptome Profiles of Near-Isogenic Hexaploid Wheat Lines Differing for Effective Alleles at the 2DL FHB Resistance QTL.Frontiers in plant science · 2018Article
- Receptor Kinases in Plant-Pathogen Interactions: More Than Pattern Recognition.The Plant cell · 2017Review
- Identification and Map-Based Cloning of the Light-Induced Lesion Mimic Mutant 1 (Frontiers in plant science · 2017Article
- Perception of Salicylic Acid inFrontiers in plant science · 2017Article
- Characterization of a Pipecolic Acid Biosynthesis Pathway Required for Systemic Acquired Resistance.The Plant cell · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis (Arabidopsis thaliana) suppressor of npr1-1, constitutive1 (snc1) contains a gain-of-function mutation in a Toll/interleukin receptor-nucleotide binding site-leucine-rich repeat Resistance (R) protein and it has been a useful tool for dissecting R-protein-mediated immunity. Here we report the identification and characterization of snc4-1D, a semidominant mutant with snc1-like phenotypes. snc4-1D constitutively expresses defense marker genes PR1, PR2, and PDF1.2, and displays enhanced pathogen resistance. Map-based cloning of SNC4 revealed that it encodes an atypical receptor-like kinase with two predicted extracellular glycerophosphoryl diester phosphodiesterase domains. The snc4-1D mutation changes an alanine to threonine in the predicted cytoplasmic kinase domain. Wild-type plants transformed with the mutant snc4-1D gene displayed similar phenotypes as snc4-1D, suggesting that the mutation is a gain-of-function mutation. Epistasis analysis showed that NON-RACE-SPECIFIC DISEASE RESISTANCE1 is required for the snc4-1D mutant phenotypes. In addition, the snc4-1D mutant phenotypes are partially suppressed by knocking out MAP KINASE SUBSTRATE1, a positive defense regulator associated with MAP KINASE4. Furthermore, both the morphology and constitutive pathogen resistance of snc4-1D are partially suppressed by blocking jasmonic acid synthesis, suggesting that jasmonic acid plays an important role in snc4-1D-mediated resistance. Identification of snc4-1D provides us a unique genetic system for analyzing the signal transduction pathways downstream of receptor-like kinases.
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