ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
Modeling the dynamics of airway constriction: effects of agonist transport and binding.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026Review
- Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome.Current opinion in physiology · 2021Review
- Breath Hold Facilitates Targeted Deposition of Aerosolized Droplets in a 3D Printed Bifurcating Airway Tree.Annals of biomedical engineering · 2021Article
- Multiscale modeling methods in biomechanics.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Hyperelastic modeling of swelling in fibrous soft tissue with application to tracheal angioedema.Journal of mathematical biology · 2016Article
- Volatile Anesthetics and the Treatment of Severe Bronchospasm: A Concept of Targeted Delivery.Drug discovery today. Disease models · 2015Article
- Modelling airway smooth muscle passive length adaptation via thick filament length distributions.Journal of theoretical biology · 2013Article
- A Bidirectional Coupling Procedure Applied to Multiscale Respiratory Modeling.Journal of computational physics · 2013Article
- Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (AirPROM).Interface focus · 2013Article
- Airway responsiveness depends on the diffusion rate of methacholine across the airway wall.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Multiscale mathematical models of airway constriction and disease.Pulmonary pharmacology & therapeutics · 2011Review
- Multi-scale lung modeling.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Computational modeling of airway and pulmonary vascular structure and function: development of a "lung physiome".Critical reviews in biomedical engineering · 2011Article
- Emergent structure-function relations in emphysema and asthma.Critical reviews in biomedical engineering · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Recent advances have revealed that during exogenous airway challenge, airway diameters cannot be adequately predicted by their initial diameters. Furthermore, airway diameters can also vary greatly in time on scales shorter than a breath. To better understand these phenomena, we developed a multiscale model that allowed us to simulate aerosol challenge in the airways during ventilation. The model incorporates agonist-receptor binding kinetics to govern the temporal response of airway smooth muscle contraction on individual airway segments, which, together with airway wall mechanics, determines local airway caliber. Global agonist transport and deposition are coupled with pressure-driven flow, linking local airway constrictions with global flow dynamics. During the course of challenge, airway constriction alters the flow pattern, redistributing the agonist to less constricted regions. This results in a negative feedback that may be a protective property of the normal lung. As a consequence, repetitive challenge can cause spatial constriction patterns to evolve in time, resulting in a loss of predictability of airway diameters. Additionally, the model offers new insights into several phenomena including the intra- and interbreath dynamics of airway constriction throughout the tree structure.
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Registered trials
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