ArticleNucleic acids research2010
PhenoHM: human-mouse comparative phenome-genome server.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Hypothesis generation for rare and undiagnosed diseases through clustering and classifying time-versioned biological ontologies.PloS one · 2024Article
- HPO2Vec+: Leveraging heterogeneous knowledge resources to enrich node embeddings for the Human Phenotype Ontology.Journal of biomedical informatics · 2019Article
- TarGo: network based target gene selection system for human disease related mouse models.Laboratory animal research · 2019Article
- Integrating phenotype ontologies with PhenomeNET.Journal of biomedical semantics · 2017Article
- Organ system heterogeneity DB: a database for the visualization of phenotypes at the organ system level.Nucleic acids research · 2015Article
- PhenoDigm: analyzing curated annotations to associate animal models with human diseases.Database : the journal of biological databases and curation · 2013Article
- Toward knowledge support for analysis and interpretation of complex traits.Genome biology · 2013Review
- Semantically enabling a genome-wide association study database.Journal of biomedical semantics · 2012Article
- The Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping data.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Computational tools for comparative phenomics: the role and promise of ontologies.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- MouseFinder: Candidate disease genes from mouse phenotype data.Human mutation · 2012Article
- Mouse genetic and phenotypic resources for human genetics.Human mutation · 2012Review
- Improving disease gene prioritization by comparing the semantic similarity of phenotypes in mice with those of human diseases.PloS one · 2012Article
- PhenomeNET: a whole-phenome approach to disease gene discovery.Nucleic acids research · 2011Article
- New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models.Briefings in functional genomics · 2011Review
- The Comparative Toxicogenomics Database: update 2011.Nucleic acids research · 2011Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
PhenoHM is a human-mouse comparative phenome-genome server that facilitates cross-species identification of genes associated with orthologous phenotypes (http://phenome.cchmc.org; full open access, login not required). Combining and extrapolating the knowledge about the roles of individual gene functions in the determination of phenotype across multiple organisms improves our understanding of gene function in normal and perturbed states and offers the opportunity to complement biologically the rapidly expanding strategies in comparative genomics. The Mammalian Phenotype Ontology (MPO), a structured vocabulary of phenotype terms that leverages observations encompassing the consequences of mouse gene knockout studies, is a principal component of mouse phenotype knowledge source. On the other hand, the Unified Medical Language System (UMLS) is a composite collection of various human-centered biomedical terminologies. In the present study, we mapped terms reciprocally from the MPO to human disease concepts such as clinical findings from the UMLS and clinical phenotypes from the Online Mendelian Inheritance in Man knowledgebase. By cross-mapping mouse-human phenotype terms, extracting implicated genes and extrapolating phenotype-gene associations between species PhenoHM provides a resource that enables rapid identification of genes that trigger similar outcomes in human and mouse and facilitates identification of potentially novel disease causal genes. The PhenoHM server can be accessed freely at http://phenome.cchmc.org.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.