ArticleAmerican journal of epidemiology2010
Parents' ages at birth and risk of adult-onset hematologic malignancies among female teachers in California.
Article in American journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Impact of maternal reproductive factors on cancer risks of offspring: A systematic review and meta-analysis of cohort studies.PloS one · 2020Pooled it
- Associations of parental age with offspring all-cause and cause-specific adult mortality.Scientific reports · 2019Article
- Article
- Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities.Scientific reports · 2017Article
- Parental Age at Birth and Risk of Hematological Malignancies in Older Adults.American journal of epidemiology · 2015Article
- The effects of advanced paternal age on fertility.Asian journal of andrology · 2013Review
- Perinatal and family risk factors for Hodgkin lymphoma in childhood through young adulthood.American journal of epidemiology · 2012Article
- Perinatal and family risk factors for non-Hodgkin lymphoma in early life: a Swedish national cohort study.Journal of the National Cancer Institute · 2012Article
- Developmental defects of the thyroid gland: relationship with advanced maternal age.Journal of clinical research in pediatric endocrinology · 2012Article
- Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.Mechanisms of ageing and development · 2011Article
- Parental ages and levels of DNA methylation in the newborn are correlated.BMC medical genetics · 2011Article
- Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Although advanced parental age at one's birth has been associated with increased risk of breast and prostate cancers, few studies have examined its effect on adult-onset sporadic hematologic malignancies. The authors examined the association of parents' ages at women's births with risk of hematologic malignancies among 110,999 eligible women aged 22-84 years recruited into the prospective California Teachers Study. Between 1995 and 2007, 819 women without a family history of hematologic malignancies were diagnosed with incident lymphoma, leukemia (primarily acute myeloid leukemia), or multiple myeloma. Multivariable-adjusted Cox proportional hazards models provided estimates of relative risks and 95% confidence intervals. Paternal age was positively associated with non-Hodgkin lymphoma after adjustment for race and birth order (relative risk for age > or =40 vs. <25 years = 1.51, 95% confidence interval: 1.08, 2.13; P-trend = 0.01). Further adjustment for maternal age did not materially alter the association. By contrast, the elevated non-Hodgkin lymphoma risk associated with advanced maternal age (> or =40 years) became null when paternal age was included in the statistical model. No association was observed for acute myeloid leukemia or multiple myeloma. Advanced paternal age may play a role in non-Hodgkin lymphoma etiology. Potential etiologic mechanisms include de novo gene mutations, aberrant paternal gene imprinting, or telomere/telomerase biology.
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Registered trials
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