ArticleVeterinary research
Conservation of mucosal associated invariant T (MAIT) cells and the MR1 restriction element in ruminants, and abundance of MAIT cells in spleen.
Article in Veterinary research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Nonclassical MHC-I Molecules: Emerging Therapeutic Targets in Next-Generation Immunotherapy.MedComm · 2026Review
- Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions.Immunological reviews · 2025Review
- A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma.Science translational medicine · 2021Article
- Mouse models illuminate MAIT cell biology.Molecular immunology · 2021Review
- Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections.Frontiers in immunology · 2021Article
- MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid BatiScience · 2020Article
- A Xenopus tadpole alternative model to study innate-like T cell-mediated anti-mycobacterial immunity.Developmental and comparative immunology · 2019Review
- Mucosal-Associated Invariant T Cells Expressing the TRAV1-TRAJ33 Chain Are Present in Pigs.Frontiers in immunology · 2019Article
- Bacterial deception of MAIT cells in a cloud of superantigen and cytokines.PLoS biology · 2017Review
- Expression and trafficking of MR1.Immunology · 2017Review
- Structure and function of the non-classical major histocompatibility complex molecule MR1.Immunogenetics · 2016Review
- Mammalian CD1 and MR1 genes.Immunogenetics · 2016Review
- Targeting Innate-Like T Cells in Tuberculosis.Frontiers in immunology · 2016Review
- Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells.The Journal of biological chemistry · 2015Review
- Coevolution of T-cell receptors with MHC and non-MHC ligands.Immunological reviews · 2015Review
- MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis.Immunological reviews · 2015Review
- The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity.Frontiers in immunology · 2015Review
- Mucosal-Associated Invariant T Cells in Multiple Sclerosis: The Jury is Still Out.Frontiers in immunology · 2015Review
- MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage.The Journal of experimental medicine · 2014Article
- Nonclassical T cells and their antigens in tuberculosis.Cold Spring Harbor perspectives in medicine · 2014Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MHC-related protein 1 (MR1) is a highly conserved MHC class I-like molecule. Human and murine mucosal associated invariant T (MAIT) cells are restricted by MR1 and express an invariant T cell receptor. Even though MR1 protein expression on the cell surface has not been demonstrated in vivo or ex vivo, it is assumed that MR1 presents a bacterial antigen from the intestinal lumen to MAIT cells because MAIT cells are present in the lamina propria and their expansion is dependent on the presence of intestinal micro flora. The existence of bovine MAIT cells and MR1 has been demonstrated recently although ovine MAIT cells and MR1 have not yet been described. We cloned bovine and ovine MR1 transcripts, including splice variants, and identified an anti human MR1 antibody that recognizes cells transfected with the bovine homolog. Using this antibody, no MR1 staining was detected using cells freshly isolated from blood, thymus, spleen, colon, ileum, and lymph node. MAIT cells are known to be enriched in the CD4/CD8 double negative peripheral blood T cell population, but their relative abundance in different tissues is not known. Comparison of the amount of MAIT cell-specific TCR transcript to the amount of constant alpha chain transcript revealed that numbers of MAIT cells are low in neonates and increase by 3-weeks of age. In 3-month old animals, MAIT cells are abundant in spleen and less so in ileum, peripheral blood, lymph node, colon, and thymus.
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