ArticleEmerging infectious diseases2010
Evolution of northeastern and midwestern Borrelia burgdorferi, United States.
Article in Emerging infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed.
- Quantifying the Public Health Impact of Lyme Disease in Minnesota: A Simulation Analysis of Reported and Unreported Cases.Journal of health economics and outcomes research · 2025Article
- Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1.PLoS pathogens · 2024Article
- Diversity and host specificity ofInfection and immunity · 2024Article
- Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1.bioRxiv : the preprint server for biology · 2024Article
- Article
- Prevalence of Borrelia burgdorferi and diversity of its outer surface protein C (ospC) alleles in blacklegged ticks (Ixodes scapularis) in Delaware.Ticks and tick-borne diseases · 2023Article
- Coupled induction of prophage and virulence factors during tick transmission of the Lyme disease spirochete.Nature communications · 2023Article
- Evolutionary ecology of Lyme Borrelia.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Review
- Vector competence studies with hard ticks and Borrelia burgdorferi sensu lato spirochetes: A review.Ticks and tick-borne diseases · 2020Review
- Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and Vaccination.The Veterinary clinics of North America. Small animal practice · 2019Review
- Primordial origin and diversification of plasmids in Lyme disease agent bacteria.BMC genomics · 2018Article
- Antimicrobial Activity of Bee Venom and Melittin against Borrelia burgdorferi.Antibiotics (Basel, Switzerland) · 2017Article
- Plasmid diversity and phylogenetic consistency in the Lyme disease agent Borrelia burgdorferi.BMC genomics · 2017Article
- Influences of Host Community Characteristics on Borrelia burgdorferi Infection Prevalence in Blacklegged Ticks.PloS one · 2017Article
- Trans-Atlantic exchanges have shaped the population structure of the Lyme disease agent Borrelia burgdorferi sensu stricto.Scientific reports · 2016Article
- Oral Immunization with OspC Does Not Prevent Tick-Borne Borrelia burgdorferi Infection.PloS one · 2016Article
- Evolutionary aspects of emerging Lyme disease in Canada.Applied and environmental microbiology · 2015Review
- Public health impact of strain specific immunity to Borrelia burgdorferi.BMC infectious diseases · 2015Article
- Recent and rapid population growth and range expansion of the Lyme disease tick vector, Ixodes scapularis, in North America.Evolution; international journal of organic evolution · 2015Article
- Evolution and population genomics of the Lyme borreliosis pathogen, Borrelia burgdorferi.Trends in genetics : TIG · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The per capita incidence of human Lyme disease in the northeastern United States is more than twice that in the Midwest. However, the prevalence of Borrelia burgdorferi, the bacterium that causes Lyme disease, in the tick vector is nearly identical in the 2 regions. The disparity in human Lyme disease incidence may result from a disparity in the human invasiveness of the bacteria in the Northeast and Midwest caused by fundamentally different evolutionary histories. B. burgdorferi populations in the Northeast and Midwest are geographically isolated, enabling evolutionary divergence in human invasiveness. However, we found that B. burgdorferi populations in the Northeast and Midwest shared a recent common ancestor, which suggests that substantial evolutionary divergence in human invasiveness has not occurred. We propose that differences in either animal ecology or human behavior are the root cause of the differences in human incidence between the 2 regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.