ArticleCritical care (London, England)2010
Elevation of cardiac troponin I during non-exertional heat-related illnesses in the context of a heatwave.
Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Maresin1 improves cardiac dysfunction via LGR6 in heatstroke.Experimental & molecular medicine · 2026Article
- Association between triglyceride-glucose index and myocardial injury in patients with heat stroke: an observational, retrospective study.Scientific reports · 2025Observational
- Environment-induced heat stress causes ventricular-dependent biochemical changes in the heart in female pigs.Physiological reports · 2025Article
- Elevated troponin levels in rhabdomyolysis as a predictor of mortality in patients with normal kidney and cardiac function.Scientific reports · 2025Article
- One day of environment-induced heat stress damages the murine myocardium.American journal of physiology. Heart and circulatory physiology · 2024Article
- Is heat wave a predictor of diarrhoea in Dhaka, Bangladesh? A time-series analysis in a South Asian tropical monsoon climate.PLOS global public health · 2024Article
- Multiparametric cardiac magnetic resonance reveals persistent myocardial inflammation in patients with exertional heat illness.European radiology · 2023Article
- Onset of cardiovascular drift during progressive heat stress in young adults (PSU HEAT project).Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- The pathogenesis and therapeutic strategies of heat stroke-induced myocardial injury.Frontiers in pharmacology · 2023Review
- Biomarkers of heatstroke-induced organ injury and repair.Experimental physiology · 2022Review
- Article
- Aging Hearts in a Hotter, More Turbulent World: The Impacts of Climate Change on the Cardiovascular Health of Older Adults.Current cardiology reports · 2022Review
- Classic and exertional heatstroke.Nature reviews. Disease primers · 2022Review
- The Cardiovascular System in Heat Stroke.CJC open · 2022Review
- Review
- Mechanism underlying the negative inotropic effect in rat left ventricle in hyperthermia: the role of TRPV1.The journal of physiological sciences : JPS · 2020Article
- Short-term effects of ambient air pollution and outdoor temperature on biomarkers of myocardial damage, inflammation and oxidative stress in healthy adults.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Salidroside pretreatment protects against myocardial injury induced by heat stroke in mice.The Journal of international medical research · 2019Article
- Effect of prealbumin level on mortality in heatstroke patients.Experimental and therapeutic medicine · 2019Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe prognostic value of cardiac troponin I (cTnI) in patients having a heat-related illness during a heat wave has been poorly documented.
methodsIn a post hoc analysis, we evaluated 514 patients admitted to emergency departments during the August 2003 heat wave in Paris, having a core temperature >38.5 degrees C and who had analysis of cTnI levels. cTnI was considered as normal, moderately elevated (abnormality threshold to 1.5 ngxmL-1), or severely elevated (>1.5 ngxmL-1). Patients were classified according to our previously described risk score (high, intermediate, and low-risk of death).
resultsMean age was 84 +/- 12 years, mean body temperature 40.3 +/- 1.2 degrees C. cTnI was moderately elevated in 165 (32%) and severely elevated in 97 (19%) patients. One-year survival was significantly decreased in patients with moderate or severe increase in cTnI (24 and 46% vs 58%, all P < 0.05). Using logistic regression, four independent variables were associated with an elevated cTnI: previous coronary artery disease, Glasgow coma scale <12, serum creatinine >120 micromolxL-1, and heart rate >110 bpm. Using Cox regression, only severely elevated cTnI was an independent prognostic factor (hazard ratio 1.93, 95% confidence interval 1.35 to 2.77) when risk score was taken into account. One-year survival was decreased in patients with elevated cTnI only in high risk patients (17 vs 31%, P = 0.04).
conclusionscTnI is frequently elevated in patients with non-exertional heat-related illnesses during a heat wave and is an independent risk factor only in high risk patients where severe increase (>1.5 ngxmL-1) indicates severe myocardial damage.
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