ArticleStem cells (Dayton, Ohio)2010
Decoded calreticulin-deficient embryonic stem cell transcriptome resolves latent cardiophenotype.
Article in Stem cells (Dayton, Ohio), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- A Systematic Analysis Identifies Key Regulators Involved in Cell Proliferation and Potential Drugs for the Treatment of Human Lung Adenocarcinoma.Frontiers in oncology · 2021Article
- NUP155 insufficiency recalibrates a pluripotent transcriptome with network remodeling of a cardiogenic signaling module.BMC systems biology · 2018Article
- Non-Endoplasmic Reticulum-Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells.Cellular and molecular life sciences : CMLS · 2018Review
- Calreticulin Is Required for TGF-β-Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells.Stem cell reports · 2017Article
- Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.Nature communications · 2016Article
- Systems biology surveillance decrypts pathological transcriptome remodeling.BMC systems biology · 2015Article
- Comparison of reprogramming genes in induced pluripotent stem cells and nuclear transfer cloned embryos.Stem cell reviews and reports · 2014Article
- Disrupted WNT signaling in mouse embryonic stem cells in the absence of calreticulin.Stem cell reviews and reports · 2014Article
- Stem cell systems informatics for advanced clinical biodiagnostics: tracing molecular signatures from bench to bedside.Croatian medical journal · 2013Review
- Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes.Stem cells (Dayton, Ohio) · 2013Review
- The computational analysis of human testis transcriptome reveals closer ties to pluripotency.Journal of human reproductive sciences · 2012Article
- Systems proteomics for translational network medicine.Circulation. Cardiovascular genetics · 2012Article
- Energy metabolism in nuclear reprogramming.Biomarkers in medicine · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Genomic perturbations that challenge normal signaling at the pluripotent stage may trigger unforeseen ontogenic aberrancies. Anticipatory systems biology identification of transcriptome landscapes that underlie latent phenotypes would offer molecular diagnosis before the onset of symptoms. The purpose of this study was to assess the impact of calreticulin-deficient embryonic stem cell transcriptomes on molecular functions and physiological systems. Bioinformatic surveillance of calreticulin-null stem cells, a monogenic insult model, diagnosed a disruption in transcriptome dynamics, which re-prioritized essential cellular functions. Calreticulin-calibrated signaling axes were uncovered, and network-wide cartography of undifferentiated stem cell transcripts suggested cardiac manifestations. Calreticulin-deficient stem cell-derived cardiac cells verified disorganized sarcomerogenesis, mitochondrial paucity, and cytoarchitectural aberrations to validate calreticulin-dependent network forecasts. Furthermore, magnetic resonance imaging and histopathology detected a ventricular septal defect, revealing organogenic manifestation of calreticulin deletion. Thus, bioinformatic deciphering of a primordial calreticulin-deficient transcriptome decoded at the pluripotent stem cell stage a reconfigured multifunctional molecular registry to anticipate predifferentiation susceptibility toward abnormal cardiophenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.