ArticleThe Journal of comparative neurology2010
Regenerated synapses in lamprey spinal cord are sparse and small even after functional recovery from injury.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Immune Activation Following Spinal Cord Injury: A Review Focused on Inflammatory Changes in the Spinal Cord.International journal of molecular sciences · 2025Review
- Temporal transcriptomic dynamics in rat spinal cord after tibial fracture unveil crosstalk between spinal cord and bone.Scientific reports · 2025Article
- Animal Models of Spinal Cord Injury.Biomedicines · 2025Review
- The Promising Role of a Zebrafish Model Employed in Neural Regeneration Following a Spinal Cord Injury.International journal of molecular sciences · 2023Review
- Proprioceptive feedback amplification restores effective locomotion in a neuromechanical model of lampreys with spinal injuries.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transneuronal Delivery of Cytokines to Stimulate Mammalian Spinal Cord Regeneration.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Lampreys and spinal cord regeneration: "a very special claim on the interest of zoologists," 1830s-present.Frontiers in cell and developmental biology · 2023Article
- The functional properties of synapses made by regenerated axons across spinal cord lesion sites in lamprey.Neural regeneration research · 2022Article
- Semaphorin signaling restricts neuronal regeneration inFrontiers in cell and developmental biology · 2022Article
- An Emerging Frontier in Intercellular Communication: Extracellular Vesicles in Regeneration.Frontiers in cell and developmental biology · 2022Review
- Activating Transcription Factor 3 (ATF3) is a Highly Conserved Pro-regenerative Transcription Factor in the Vertebrate Nervous System.Frontiers in cell and developmental biology · 2022Review
- Swimming kinematics and performance of spinal transected lampreys with different levels of axon regeneration.The Journal of experimental biology · 2021Article
- Regulation of UNC-40/DCC and UNC-6/Netrin by DAF-16 promotes functional rewiring of the injured axon.Development (Cambridge, England) · 2021Article
- Survival and Axonal Outgrowth of the Mauthner Cell Following Spinal Cord Crush Does Not Drive Post-injury Startle Responses.Frontiers in cell and developmental biology · 2021Article
- Source of Early Regenerating Axons in Lamprey Spinal Cord Revealed by Wholemount Optical Clearing with BABB.Cells · 2020Article
- Mito Hacker: a set of tools to enable high-throughput analysis of mitochondrial network morphology.Scientific reports · 2020Article
- Building bridges, not walls: spinal cord regeneration in zebrafish.Disease models & mechanisms · 2020Review
- The various routes to functional regeneration in the central nervous system.Communications biology · 2020Article
- Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys.Disease models & mechanisms · 2019Article
- Regenerative capacity in the lamprey spinal cord is not altered after a repeated transection.PloS one · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Despite the potential importance that synapse regeneration plays in restoring neuronal function after spinal cord injury (SCI), even the most basic questions about the morphology of regenerated synapses remain unanswered. Therefore, we set out to gain a better understanding of central synapse regeneration by examining the number, distribution, molecular composition, and ultrastructure of regenerated synapses under conditions in which behavioral recovery from SCI was robust. To do so, we used the giant reticulospinal (RS) neurons of lamprey spinal cord because they readily regenerate, are easily identifiable, and contain large synapses that serve as a classic model for vertebrate excitatory neurotransmission. Using a combination of light and electron microscopy, we found that regenerated giant RS synapses regained the basic structures and presynaptic organization observed at control giant RS synapses at a time when behavioral recovery was nearly complete. However, several obvious differences remained. Most strikingly, regenerated giant RS axons produced very few synapses. In addition, presynaptic sites within regenerated axons were less complex, had fewer vesicles, and had smaller active zones than normal. In contrast, the densities of presynapses and docked vesicles were nearly restored to control values. Thus, robust functional recovery from SCI can occur even when the structures of regenerated synapses are sparse and small, suggesting that functional recovery is due to a more complex set of compensatory changes throughout the spinal network.
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