ArticleThe Journal of comparative neurology2010
Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the rat.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed, 156 citations in OpenAlex.
- Postnatal maturation of the basolateral and paralaminar amygdala in rodents: implications for social-emotional development.Frontiers in neuroscience · 2026Review
- Development of the Nervous System During Adolescence.Advances in experimental medicine and biology · 2026Review
- Prefrontal cortex development and its implications in mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Emotion Regulation in the Preadolescent Brain and the Role of Individual Temperamental Differences.Brain and behavior · 2025Article
- The beautiful adolescent brain: An evolutionary developmental perspective.Annals of the New York Academy of Sciences · 2025Review
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Development of the rodent prefrontal cortex: circuit formation, plasticity, and impacts of early life stress.Frontiers in neural circuits · 2025Review
- Developmental Shifts in Amygdala Function.Current topics in behavioral neurosciences · 2025Review
- Microglia Morphology in the Developing Primate Amygdala and Effects of Early Life Stress.eNeuro · 2025Article
- Developmental and molecular contributions to contextual fear memory emergence in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Long-lasting effects of disturbing the circadian rhythm or sleep in adolescence.Brain research bulletin · 2024Review
- Annual Research Review: Neuroimmune network model of depression: a developmental perspective.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Synaptic pruning during adolescence shapes adult social behavior in both males and females.Developmental psychobiology · 2024Article
- Corticolimbic connectivity mediates the relationship between pubertal timing and mental health problems.Psychological medicine · 2023Article
- Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice.Neurotoxicology · 2023Article
- Neural Circuit Transitions Supporting Developmentally Specific Social Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Neural patterns of threat response in adolescents predict vulnerability for and resilience against internalizing symptoms during COVID-19 waves.Neuroimage. Reports · 2023Article
- Effects of Escitalopram on the Functional Neural Circuits in an Animal Model of Adolescent Depression.Molecular imaging and biology · 2023Article
- Maturation of a cortical-amygdala circuit limits sociability in male rats.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Amygdala circuit transitions supporting developmentally-appropriate social behavior.Neurobiology of learning and memory · 2023Review
44 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
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Abstract
Transformations in affective and social behaviors, many of which involve amygdalar circuits, are hallmarks of adolescence in many mammalian species. In this study, using the rat as a model, we provide the first evidence that afferents of the basal amygdala (BA) undergo significant structural remodeling during adolescence. We used quantitative tract-tracing and gene expression profiling methods to characterize changes in the medial prefrontal cortical (mPFC) inputs to the BA across ages analogous to the late juvenile period [postnatal day (P) 25], late adolescence (P45), and adulthood (P90) in the rat. As assessed after deposition of Fluorogold into the BA, the number of BA-projecting neurons in the mPFC remained stable between P25 and P45 but decreased by about 50% between P45 and P90. Anterograde tract tracing with biotin dextran amine deposits centered in the ventral prelimbic cortex revealed that, during this period, the density of mPFC-derived axon terminals in the BA also decrease significantly, an effect particularly evident in the dorsal basolateral nucleus. Within the BA, there were also highly significant changes in gene expression indicative of neurite or synaptic plasticity, most notably in the Ras/GTPase superfamily, and in pathways that regulate cytoskeletal dynamics and steroid synthesis/lipid metabolism. These data provide convergent evidence that mPFC inputs to the BA are pruned during late adolescence or early adulthood. Moreover, the structural remodeling within these afferents may be accompanied by significant changes in neurite plasticity within the BA.
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