ArticleArthritis and rheumatism2010
Generalized bone loss as a predictor of three-year radiographic damage in African American patients with recent-onset rheumatoid arthritis.
Article in Arthritis and rheumatism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Metformin Treatment Reduces the Incidence of Rheumatoid Arthritis: A Two-Sample Mendelian Randomized Study.Journal of clinical medicine · 2023Article
- Bone Loss and Radiographic Damage Profile in Rheumatoid Arthritis Moroccan Patients.Journal of bone metabolism · 2021Article
- Associations of alcohol use with radiographic disease progression in African Americans with recent-onset rheumatoid arthritis.The Journal of rheumatology · 2013Article
- Racial and ethnic disparities in rheumatoid arthritis.Current rheumatology reports · 2012Review
- Bone mineral density changes during treatment of rheumatoid arthritis with disease-modifying-anti-rheumatic drugs.Caspian journal of internal medicine · 2012Article
- Bone mineral density changes in patients with recent-onset rheumatoid arthritis.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2011Article
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Authors and funding
13 authors.
Funding
Abstract
objectiveTo examine the association between baseline bone mineral density (BMD) and radiographic damage at 3 years of disease duration in a longitudinal cohort of African Americans with recent-onset rheumatoid arthritis (RA).
methodsAfrican American RA patients with a disease duration of <2 years (n = 141) were included in the study. All patients underwent baseline BMD measurements (femoral neck and/or lumbar spine) using dual x-ray absorptiometry. T scores were calculated using normative data from the general population of African Americans. Patients were categorized as having osteopenia/osteoporosis (T score less than or equal to -1) or as being healthy. Hand and wrist radiographs, obtained at baseline and at 3 years of disease duration, were scored using the modified Sharp/van der Heijde method. The association between baseline BMD and total radiographic score at 3 years of disease was examined using multivariable negative binomial regression.
resultsAt baseline, the mean age and the mean disease duration were 52.4 years and 14.8 months, respectively; 85.1% of the patients were women. The average total radiographic scores at baseline and at 3 years of disease were 2.4 and 5.7, respectively. In the final reduced multivariable model, adjusting for age, sex, anti-cyclic citrullinated peptide antibody positivity, and the presence of radiographic damage at baseline, the total radiographic score at 3 years disease in patients with osteopenia/osteoporosis of the femoral neck was twice that in patients with normal bone density, and the difference was statistically significant (P = 0.0084). No association between lumbar spine osteopenia/osteoporosis and radiographic score was found.
conclusionOur findings suggest that reduced generalized BMD may be a predictor of future radiographic damage and support the hypothesis that radiographic damage and reduced generalized BMD in RA patients may share a common pathogenic mechanism.
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