ArticleJournal of assisted reproduction and genetics2010
Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice.
Article in Journal of assisted reproduction and genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- Silver Nanoparticles Loaded with Oleuropein Reduce Doxorubicin-Induced Testicular Damage by Regulating Endoplasmic Reticulum Stress, and Apoptosis.Biological trace element research · 2024Article
- The Role of Selected Natural Biomolecules in Sperm Production and Functionality.Molecules (Basel, Switzerland) · 2021Review
- Green tea consumption increases sperm concentration and viability in male rats and is safe for reproductive, liver and kidney health.Scientific reports · 2020Article
- Testing for paternal influences on offspring telomere length in a human cohort in the Philippines.American journal of physical anthropology · 2020Article
- The effect of green tea extract on the sperm parameters and histological changes of testis in rats exposed to para-nonylphenol.International journal of reproductive biomedicine · 2019Article
- Protective effect of green tea extract on the deltamethrin-induced toxicity in mice testis: An experimental study.International journal of reproductive biomedicine · 2019Article
- Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs.Advances in pharmacological sciences · 2018Article
- Follicle-stimulating hormone enhances recovery from low-dose doxorubicin-induced spermatogenic disorders in mice.Journal of assisted reproduction and genetics · 2015Article
- Green tea infusion improves cyclophosphamide-induced damage on male mice reproductive system.Toxicology reports · 2015Article
- Royal Jelly alleviates sperm toxicity and improves in vitro fertilization outcome in Stanozolol-treated mice.Iranian journal of reproductive medicine · 2015Article
- Evaluating the effects of Escanbil (Calligonum) extract on the expression level of Catsper gene variants and sperm motility in aging male mice.Iranian journal of reproductive medicine · 2014Article
- Crataegus monogyna fruit aqueous extract as a protective agent against doxorubicin-induced reproductive toxicity in male rats.Avicenna journal of phytomedicine · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to investigate the protective effect of green tea extracts against doxorubicin-induced damage in the mouse testes correlating with telomerase activity.
methodsGreen tea extracts were administered orally. Doxorubicin was coadministered intraperitoneally. These testes were evaluated histologically and the telomerase activity was analyzed. Additional immunostaining was carried out.
resultsBoth the sperm density and sperm motility were significantly increased in green tea extracts coadministration groups as compared to the doxorubicin-treated groups. By histological analysis, germ cell damage was greatly attenuated by green tea extracts coadministration. Telomerase activity significantly increased in association with the coadministration of green tea extracts as compared to that of doxorubicin-only groups. In all groups, human telomerase reverse transcriptase signals were mainly observed in the spermatocytes and spermatids.
conclusionsThese findings suggest that green tea extracts exert protective effects against doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity levels.
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