Evidence map›Paper›PMID 20505956›Full record

GuidelineSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2011

Antiemetic therapy for multiple-day chemotherapy and additional topics consisting of rescue antiemetics and high-dose chemotherapy with stem cell transplant: review and consensus statement.

Lawrence H Einhorn, Steven M Grunberg, Bernardo Rapoport, Cynthia Rittenberg, Petra Feyer

Registry-linked trialAbstract readConsensus StatementPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02939287 (Aprepitant- and Olanzapine- Containing Regimens for Prevention of Acute and Delayed Nausea and Vomiting Associated With High Dose Melphalan and BEAM in Autologous Stem Cell Transplant Patients), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02939287 phase3completednot on this mapstarted 2017, after this paper: background citation

Aprepitant- and Olanzapine- Containing Regimens for Prevention of Acute and Delayed Nausea and Vomiting Associated With High Dose Melphalan and BEAM in Autologous Stem Cell Transplant Patients

TypeinterventionalSponsorRush University Medical CenterRan2017 to 2022Enrolled52ConditionsNausea, VomitingArmso Aprepitant 125 mg orally one hour prior to chemotherapy on Day -1 and 80 mg orally on Days 0 and +1, Olanzapine10 mg orally daily on Days -1,0,+1 and +2, Aprepitant plus Olanzapine
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. SEOM guide to antiemetic prophylaxis in cancer patients treated with chemotherapy 2013.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2013
    Guideline
  2. Trial
  3. Results of a 7-day aprepitant schedule for the prevention of nausea and vomiting in 5-day cisplatin-based germ cell tumor chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
    Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Response.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015
    Article
  11. Chemotherapy induced nausea and vomiting in bone marrow transplant: the unmet need.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015
    Article
  12. Review
  13. Safety and pharmacokinetic evaluation of repeated intravenous administration of palonosetron 0.75 mg in patients receiving highly or moderately emetogenic chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014
    Article
  14. Observational
  15. Obstacles to managing chemotherapy-induced nausea and vomiting in high-dose chemotherapy with stem cell transplant.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Lawrence H EinhornDivision of Hematology-Oncology, Mel and Bren Simon Cancer Center, Indiana University, 535 Barnhill Room 473, Indianapolis, IN 46202-5289, USA. leinhorn@iupui.edu
Steven M Grunberg
Bernardo Rapoport
Cynthia Rittenberg
Petra Feyer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper will evaluate various topics related to chemotherapy-induced nausea and vomiting. The results published reflect a consensus conference convened in Perugia, Italy. The topics discussed include antiemetic therapy of multiple-day chemotherapy, high-dose chemotherapy, and rescue antiemetics.

Indexed as

AntiemeticsAntineoplastic AgentsDexamethasoneDose-Response Relationship, DrugDrug Administration ScheduleHumansNauseaSerotonin 5-HT3 Receptor AntagonistsStem Cell TransplantationVomitingAntiemeticsAntineoplastic AgentsDexamethasoneSerotonin 5-HT3 Receptor Antagonists

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.