Trial reportEuropean journal of nuclear medicine and molecular imaging2010
18F-fluoride PET/CT for detection of sacroiliitis in ankylosing spondylitis.
Trial report in European journal of nuclear medicine and molecular imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Validation of quantitative [Annals of nuclear medicine · 2025Pooled it
- [Long version on the S3 guidelines for axial spondyloarthritis including Bechterew's disease and early forms, Update 2019 : Evidence-based guidelines of the German Society for Rheumatology (DGRh) and participating medical scientific specialist societies and other organizations].Zeitschrift fur Rheumatologie · 2019Guideline
- [German Society for Rheumatology S3 guidelines on axial spondyloarthritis including Bechterew's disease and early forms: 6 Diagnostics].Zeitschrift fur Rheumatologie · 2014Guideline
- Efficacy and safety of [European journal of nuclear medicine and molecular imaging · 2026Trial
- Diagnostic accuracy ofEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Non-FDG PET/CT imaging of inflammatory arthritis.Skeletal radiology · 2025Review
- [Biomolecules · 2024Review
- Article
- The Use ofDiagnostics (Basel, Switzerland) · 2024Article
- Use of Multimodality Imaging in the Evaluation of Patients With Spondyloarthropathies and Sacroiliitis.Cureus · 2024Review
- Adalimumab and sulfasalazine in alleviating sacroiliac and aortic inflammation detected in PET/CT in patients with axial spondyloarthritis: PETSPA.Immunity, inflammation and disease · 2022Article
- Review
- Review
- Clinical utility of F-18 sodium fluoride PET/CT for estimating disease activity in patients with rheumatoid arthritis.Quantitative imaging in medicine and surgery · 2021Article
- Classification vs diagnostic criteria: the challenge of diagnosing axial spondyloarthritis.Rheumatology (Oxford, England) · 2020Review
- Fusion and Healing Prediction in Posterolateral Spinal Fusion UsingDiagnostics (Basel, Switzerland) · 2020Article
- Performance ofArthritis research & therapy · 2019Article
- Osteoid osteoma: multimodality imaging with focus on hybrid imaging.European journal of nuclear medicine and molecular imaging · 2019Review
- Bone formation in ankylosing spondylitis during anti-tumour necrosis factor therapy imaged by 18F-fluoride positron emission tomography.Rheumatology (Oxford, England) · 2018Article
- The Role of Imaging in Diagnosing Axial Spondyloarthritis.Frontiers in medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to evaluate the performance of (18)F-fluoride-PET/CT (PET/CT) for the diagnosis of sacroiliac joint (SIJ) arthritis in patients with active ankylosing spondylitis (AS).
methodsIncluded in the study were 15 patients with AS according to the modified New York criteria (AS group) and with active disease and 13 patients with mechanical low back pain (MLBP; control group) who were investigated with whole-body (18)F-fluoride PET/CT. The ratio of the uptake in the SIJ and that in the sacrum (SIJ/S) was calculated for every joint.
resultsThe mean SIJ/S ratio of 30 quantified joints in the AS group was 1.66 (range 1.10-3.07) with PET/CT, and the mean SIJ/S ratio of 26 quantified joints in the MLBP group was 1.12 (range 0.71-1.52). The area under the receiver operating characteristic curve for SIJ arthritis was 0.84. With plain radiography as a the gold standard and taking an SIJ/S ratio of >1.3 as the threshold, the sensitivity, specificity and accuracy on a per patient basis were 80%, 77% and 79%, respectively. On a per SIJ basis, the greatest sensitivity (94%) was found in grade 3 sacroiliitis (n = 16).
conclusionOur results suggest that quantitative (18)F-fluoride PET/CT may play a role in the diagnosis of sacroiliitis in active AS and is an alternative to conventional bone scintigraphy in times of molybdenum shortage.
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Registered trials
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