Trial reportJournal of human hypertension2011
Contribution of nitric oxide to the blood pressure and arterial responses to exercise in humans.
Trial report in Journal of human hypertension, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- A systematic review on the effect of acute aerobic exercise on arterial stiffness reveals a differential response in the upper and lower arterial segments.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Pooled it
- The acute effect of passively assisted trunk stretching on central arterial stiffness and blood pressure in middle-aged to older adults.European journal of applied physiology · 2024Trial
- Effects of resistance exercise training on resting and post-exercise forearm blood flow and wave reflection in overweight and obese women.Journal of human hypertension · 2012Trial
- Creatine supplementation attenuates hemodynamic and arterial stiffness responses following an acute bout of isokinetic exercise.European journal of applied physiology · 2011Trial
- Altered arterial stiffness and subendocardial viability ratio in young healthy light smokers after acute exercise.PloS one · 2011Trial
- Mechanisms of exercise-induced reduction in peripheral arterial stiffness.European journal of applied physiology · 2025Article
- Baseline arterial stiffness does not influence post-exercise reduction in pulse wave velocity.Physiological reports · 2025Article
- Estradiol levels are differentially associated with pulse wave velocity in trauma-exposed premenopausal women with and without PTSD.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Association Between Recovery Systolic Blood Pressure After Spot Marching Exercise and Vascular Function in Middle-Aged Adults.Vascular health and risk management · 2025Article
- Impact of an active lifestyle on cardiovascular autonomic modulation and oxidative stress in males with overweight and parental history of hypertension.Journal of human hypertension · 2024Article
- Arterial Stiffness following Endurance and Resistance Exercise Sessions in Older Patients with Coronary Artery Disease.International journal of environmental research and public health · 2022Article
- Low Vitamin D Status Relates to the Poor Response of Peripheral Pulse Wave Velocity Following Acute Maximal Exercise in Healthy Young Men.Nutrients · 2022Article
- Safety, efficacy and delivery of isometric resistance training as an adjunct therapy for blood pressure control: a modified Delphi study.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- The Acute Effect of Exercise on Arterial Stiffness in Healthy Subjects: A Meta-Analysis.Journal of clinical medicine · 2021Review
- Renoprotection Induced by Aerobic Training Is Dependent on Nitric Oxide Bioavailability in Obese Zucker Rats.Oxidative medicine and cellular longevity · 2021Article
- Article
- Acute Effects of Exercise Mode on Arterial Stiffness and Wave Reflection in Healthy Young Adults: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2018Article
- Carotid femoral pulse wave velocity in type 2 diabetes and hypertension: capturing arterial health effects of step counts.Journal of hypertension · 2017Article
- Exercise blood pressure: clinical relevance and correct measurement.Journal of human hypertension · 2015Review
- Ivabradine therapy to unmask heart rate-independent effects of β-blockers on pulse wave reflections.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
An exaggerated blood pressure (BP) response to exercise predicts future cardiovascular risk. The mechanisms underlying exercise-induced hypertension remain unclear, although endothelial dysfunction and elevated arterial stiffness may contribute. Given the association between reductions in nitric oxide (NO) and vascular dysfunction, we sought to determine whether acute inhibition of NO synthase with N(G)-monomethyl-L-arginine (L-NMMA) would lead to exaggerated BP responses to maximal exercise and attenuate exercise-induced reductions in arterial stiffness. In 10 healthy subjects (31±5 years), BP and heart rate (HR) were measured before, during and after an incremental cycling exercise test to determine maximal oxygen consumption (VO(2)max). Trials were performed with placebo (saline) or intravenous infusion of L-NMMA on separate days in a randomized, double-blind, crossover design. Central (aortic) and peripheral (femoral) arterial stiffness were assessed using pulse wave velocity (PWV). BP was increased with L-NMMA at rest and during sub-maximal exercise, but not at maximal exercise (mean BP 117±5 vs 118±8 mm Hg, saline vs L-NMMA, P>0.05). Furthermore, L-NMMA had no influence on exercising HR or VO(2)max (P<0.05). Notably, aortic PWV was similarly increased after exercise with either saline or L-NMMA (P<0.05), whereas postexercise decreases in femoral PWV were attenuated with L-NMMA (P<0.05). Our findings suggest that NO is an important contributor to reductions in femoral artery stiffness after maximal exercise in healthy individuals. Furthermore, acute pharmacological inhibition of NO synthase causes augmented BP responses to sub-maximal exercise, but does not lead to exaggerated BP responses to maximal exercise or reduce maximal oxygen consumption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.