Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Effect of modafinil on impairments in neurobehavioral performance and learning associated with extended wakefulness and circadian misalignment.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Pharmacological interventions for sleepiness and sleep disturbances caused by shift work.The Cochrane database of systematic reviews · 2014Pooled it
- Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans.Journal of studies on alcohol and drugs · 2011Trial
- Blue light restores functional circadian clocks in eyeless cave spiders.Science advances · 2025Article
- Influence of circadian phase and extended wakefulness on glucose levels during forced desynchrony.Sleep health · 2024Article
- Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period.Nature protocols · 2023Review
- A classification approach to estimating human circadian phase under circadian alignment from actigraphy and photometry data.Journal of pineal research · 2021Article
- An ensemble mixed effects model of sleep loss and performance.Journal of theoretical biology · 2021Article
- Stem-leaf saponins fromJournal of ginseng research · 2020Article
- Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation.British journal of pharmacology · 2019Article
- Young adults are more vulnerable to chronic sleep deficiency and recurrent circadian disruption than older adults.Scientific reports · 2018Article
- Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine.Biology · 2016Review
- Article
- Synchrony and desynchrony in circadian clocks: impacts on learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- Sleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions.Journal of sleep research · 2015Article
- Wake-promoting pharmacotherapy for psychiatric disorders.Current psychiatry reports · 2014Review
- Ventral striatal prediction error signaling is associated with dopamine synthesis capacity and fluid intelligence.Human brain mapping · 2013Article
- Classifying performance impairment in response to sleep loss using pattern recognition algorithms on single session testing.Accident; analysis and prevention · 2013Article
- Circadian and wakefulness-sleep modulation of cognition in humans.Frontiers in molecular neuroscience · 2012Article
- Sex difference in the near-24-hour intrinsic period of the human circadian timing system.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Although worldwide millions of people work prolonged hours, at adverse circadian phases, evidence suggests that cognitive function is impaired under these conditions with important societal consequences. In a double-blind placebo-controlled laboratory-based study, we investigated the effect of the wakefulness-promoting drug modafinil as a countermeasure against such neurobehavioral impairments induced by both prolonged wakefulness and circadian misalignment. Neurobehavioral performance, alertness, and sleep were studied in young healthy participants (N=18) who underwent a 25-day forced desynchrony protocol in which the period of the sleep-wakefulness cycle was scheduled to be 42.85 h (duration of each wakefulness episode: 28.57 h; sleep/rest episode: 14.28 h). Each waking day, participants were treated with either 400 mg modafinil, divided into three doses, or placebo, according to a randomized, parallel-group design. Treatment with modafinil significantly attenuated the performance decrements seen for several parameters including cognitive-psychomotor speed, visual attention and reaction times both with progressive hours awake and when working at adverse circadian phases. Subjective alertness and sleep parameters were similar between treatment groups, but modafinil-treated participants had fewer bouts of inadvertent sleep during scheduled waking. Modafinil reduced the neurobehavioral impairment associated with work, both during prolonged wakefulness and at adverse circadian phases, without adversely affecting subjective alertness or subsequent sleep. These features suggest that modafinil might be a particularly relevant countermeasure against the deleterious effects of prolonged work hours, shift work, and transmeridian travel.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.