ArticlePsychiatric genetics2010
Genome-wide scan for self-rating of the effects of alcohol in American Indians.
Article in Psychiatric genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Genome-wide association studies of the self-rating of effects of ethanol (SRE).Addiction biology · 2020Pooled it
- Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity.Alcoholism, clinical and experimental research · 2018Pooled it
- Genetic influences on alcohol sensitivity: A critical review.Current addiction reports · 2024Article
- Genomics and inclusion of Indigenous peoples in high income countries.Human genetics · 2023Review
- Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans.Brain sciences · 2020Review
- A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.Alcoholism, clinical and experimental research · 2018Review
- Endophenotypes for Alcohol Use Disorder: An Update on the Field.Current addiction reports · 2015Article
- Associations between a history of binge drinking during adolescence and self-reported responses to alcohol in young adult Native and Mexican Americans.Alcoholism, clinical and experimental research · 2014Article
- CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2014Article
- A brief history of research on the genetics of alcohol and other drug use disorders.Journal of studies on alcohol and drugs. Supplement · 2014Review
- Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire.Drug and alcohol dependence · 2013Article
- Evidence for a genetic component for substance dependence in Native Americans.The American journal of psychiatry · 2013Review
- Heritability of level of response and association with recent drinking history in nonalcohol-dependent drinkers.Alcoholism, clinical and experimental research · 2012Article
- Event-related oscillations to affective stimuli: heritability, linkage and relationship to externalizing disorders.Journal of psychiatric research · 2012Article
- Linkage analyses of stimulant dependence, craving, and heavy use in American Indians.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThis study's aims were to map loci linked to self-rating of the effects of alcohol and to determine if there was overlap with loci mapped earlier for other substance dependence phenotypes in an American Indian community at high risk for substance dependence.
methodsEach participant gave a blood sample and completed a structured diagnostic interview using the Semi Structured Assessment for the Genetics of Alcoholism. Retrospective report of responses to alcohol during the FIRST FIVE TIMES they had ever drank alcohol was estimated from the Self-Rating of the Effects of Alcohol (SRE) questionnaire for each participant. Genotypes were determined for a panel of 791 micro-satellite polymorphisms in 381 members of multiplex families using SOLAR.
resultsAnalyses of multipoint variance component Log of Odds (LOD) scores, for the FIRST FIVE TIMES phenotype, revealed two loci that had a LOD score greater than 3.0 on chromosomes 6 and 9. In addition, three locations were identified with LOD scores above 2.0 on chromosomes 10, 12, 17.
conclusionThese results corroborate the importance of regions on chromosome 6 and 9 highlighted in earlier segregation studies in this and other populations for substance dependence-related phenotypes, as well as an area on chromosome 10 earlier identified for the FIRST FIVE TIMES phenotype in the collaborative study on the genetics of alcoholism. These studies additionally lend further support the construct that the SRE may represent an important endophenotype associated with alcohol and other substance dependence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.