ArticleEpigenetics2010
Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues.
Article in Epigenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites.Clinical epigenetics · 2023Pooled it
- Molecular remodeling of adipose tissue is associated with metabolic recovery after weight loss surgery.Journal of translational medicine · 2022Trial
- Pyrosequencing versus methylation-specific PCR for assessment of MGMT methylation in tumor and blood samples of glioblastoma patients.Scientific reports · 2019Trial
- DNA methyltransferase inhibitors in oncology: clinical progress, limitations and future directions.Epigenomics · 2026Review
- Integration of epigenetics into ecotoxicology: insights and fundamental research needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- DNA methylation confers a cerebellum-specific identity in non-human primates.Zoological research · 2025Article
- Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis.Journal of translational medicine · 2025Article
- Detection and Characterization of Methylated Circulating Tumor DNA in Gastric Cancer.International journal of molecular sciences · 2024Article
- An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions.International journal of molecular sciences · 2024Review
- Article
- DNA methylation across the tree of life, from micro to macro-organism.Bioengineered · 2022Article
- Article
- DNA Methylation Profiles of Purified Cell Types in Bronchoalveolar Lavage: Applications for Mixed Cell Paediatric Pulmonary Studies.Frontiers in immunology · 2021Observational
- Characterization of DNA methylation-based markers for human body fluid identification in forensics: a critical review.International journal of legal medicine · 2020Review
- Epigenome-wide DNA methylation in placentas from preterm infants: association with maternal socioeconomic status.Epigenetics · 2019Article
- The Role of Methylated Circulating Nucleic Acids as a Potential Biomarker in Alzheimer's Disease.Molecular neurobiology · 2019Article
- Disease prediction by cell-free DNA methylation.Briefings in bioinformatics · 2019Review
- Comparing DNA methylation profiles in saliva and intestinal mucosa.BMC genomics · 2019Article
- Evaluation of two independent protocols for the extraction of DNA and RNA from different tissues of sea cucumberMethodsX · 2019Article
- Placental CpG methylation of HPA-axis genes is associated with cognitive impairment at age 10 among children born extremely preterm.Hormones and behavior · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Although most CpG islands are generally thought to remain unmethylated in all adult somatic tissues, recent genome-wide approaches have found that some CpG islands have distinct methylation patterns in various tissues, with most differences being seen between germ cells and somatic tissues. Few studies have addressed this among human somatic tissues and fewer still have studied the same sets of tissues from multiple individuals. In the current study, we used Restriction Landmark Genomic Scanning to study tissue specific methylation patterns in a set of twelve human tissues collected from multiple individuals. We identified 34 differentially methylated CpG islands among these tissues, many of which showed consistent patterns in multiple individuals. Of particular interest were striking differences in CpG island methylation, not only among brain regions, but also between white and grey matter of the same region. These findings were confirmed for selected loci by quantitative bisulfite sequencing. Cluster analysis of the RLGS data indicated that several tissues clustered together, but the strongest clustering was in brain. Tissues from different brain regions clustered together, and, as a group, brain tissues were distinct from either mesoderm or endoderm derived tissues which demonstrated limited clustering. These data demonstrate consistent tissue specific methylation for certain CpG islands, with clear differences between white and grey matter of the brain. Furthermore, there was an overall pattern of tissue specifically methylated CpG islands that distinguished neural tissues from non-neural.
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