ArticlePhysical biology2010
A comparison of deterministic and stochastic simulations of neuronal vesicle release models.
Article in Physical biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Electrodiffusion dynamics in the cardiomyocyte dyad at nano-scale resolution using the Poisson-Nernst-Planck (PNP) equations.PLoS computational biology · 2025Article
- Close agreement between deterministic versus stochastic modeling of first-passage time to vesicle fusion.Biophysical journal · 2022Article
- Influence of T-Bar on Calcium Concentration Impacting Release Probability.Frontiers in computational neuroscience · 2022Article
- A first-passage approach to diffusion-influenced reversible binding and its insights into nanoscale signaling at the presynapse.Scientific reports · 2021Article
- Spatiotemporal model of tripartite synapse with perinodal astrocytic process.Journal of computational neuroscience · 2020Article
- RIM-binding proteins recruit BK-channels to presynaptic release sites adjacent to voltage-gated CaThe EMBO journal · 2018Article
- Variations in CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The First 100 nm Inside the Pre-synaptic Terminal Where Calcium Diffusion Triggers Vesicular Release.Frontiers in synaptic neuroscience · 2018Review
- Hybrid Markov-mass action law model for cell activation by rare binding events: Application to calcium induced vesicular release at neuronal synapses.Scientific reports · 2016Article
- A Simple, Realistic Stochastic Model of Gastric Emptying.PloS one · 2016Article
- Short-term plasticity constrains spatial organization of a hippocampal presynaptic terminal.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Theory of active transport in filopodia and stereocilia.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- How does the ryanodine receptor in the ventricular myocyte wake up: by a single or by multiple open L-type Ca2+ channels?European biophysics journal : EBJ · 2012Article
- Cardiac myocytes and local signaling in nano-domains.Progress in biophysics and molecular biology · 2011Review
- Modelling vesicular release at hippocampal synapses.PLoS computational biology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
We study the calcium-induced vesicle release into the synaptic cleft using a deterministic algorithm and MCell, a Monte Carlo algorithm that tracks individual molecules. We compare the average vesicle release probability obtained using both algorithms and investigate the effect of the three main sources of noise: diffusion, sensor kinetics and fluctuations from the voltage-dependent calcium channels (VDCCs). We find that the stochastic opening kinetics of the VDCCs are the main contributors to differences in the release probability. Our results show that the deterministic calculations lead to reliable results, with an error of less than 20%, when the sensor is located at least 50 nm from the VDCCs, corresponding to microdomain signaling. For smaller distances, i.e. nanodomain signaling, the error becomes larger and a stochastic algorithm is necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.