ArticleScience translational medicine2010
Metabolic signatures of exercise in human plasma.
Article in Science translational medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02561377 (Effect of Resistance Training on Metabolic Control and Outcome in Prediabetes), which is not on this map. Cited by 237 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Resistance Training on Metabolic Control and Outcome in Prediabetes (NMR-based Metabonomics)
Who cites it
237 citing papers in PubMed, 3 syntheses or guidelines pooled it, 421 citations in OpenAlex.
- A Single Exercise Session Elicits a Transient Kynurenine Metabolic Signature in Health and Disease: A Systematic Review and Meta-Analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Pooled it
- The Ergogenic Potential of Succinic Acid in Exercise Performance and Post-Exercise Recovery: A Systematic Review.Nutrients · 2026Pooled it
- Elucidating regulatory processes of intense physical activity by multi-omics analysis.Military Medical Research · 2023Pooled it
- Metabolomic profiling of intensity-dependent responses to acute exercise in healthy humans.Journal of translational medicine · 2026Trial
- Carbohydrate restriction drives greater perturbations in circulating metabolites than low energy availability in elite male athletes.Physiological reports · 2026Trial
- Effects of Heat Exposure on Kynurenine Pathway Metabolism-Comparison Between Exertional and Exogenous Heating of the Human Body.Acta physiologica (Oxford, England) · 2025Trial
- Impact of recognition of genetic information related to BMI on changes in physical activity, dietary intake, and blood cholesterol level: a randomized controlled trial.European journal of nutrition · 2025Trial
- Testosterone plus lifestyle therapy improves skeletal muscle glycolysis in older men with obesity and hypogonadism.Frontiers in endocrinology · 2025Trial
- Hydrogen-Rich Gas Enhanced Sprint-Interval Performance: Metabolomic Insights into Underlying Mechanisms.Nutrients · 2024Trial
- Exercise increases TCA intermediate concentrations during low-calorie diet independent of insulin resistance among women with obesity.Physiological reports · 2024Trial
- Metabolomic, hormonal and physiological responses to hypoglycemia versus euglycemia during exercise in adults with type 1 diabetes.BMJ open diabetes research & care · 2020Trial
- Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women.Physiological reports · 2020Trial
- Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid.European journal of applied physiology · 2020Trial
- Skeletal muscle Nur77 and NOR1 insulin responsiveness is blunted in obesity and type 2 diabetes but improved after exercise training.Physiological reports · 2019Trial
- Plasma Metabolite Profiles in Response to Chronic Exercise.Medicine and science in sports and exercise · 2018Trial
- Military training elicits marked increases in plasma metabolomic signatures of energy metabolism, lipolysis, fatty acid oxidation, and ketogenesis.Physiological reports · 2017Trial
- Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea).Circulation · 2017Trial
- Exercise Metabolomics Reveals Intensity-Dependent Metabolic Responses Associated with Cardiorespiratory Fitness in Adults with Type 1 Diabetes.Metabolites · 2026Article
- Review
- From Routine Blood Tests to Metabolomics: A Contextual Framework for Interpreting Biomarkers of Training Load, Recovery, and Metabolic Stress in Athletes.Metabolites · 2026Review
177 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 5 institutions in 1 country.
Funding
Abstract
Exercise provides numerous salutary effects, but our understanding of how these occur is limited. To gain a clearer picture of exercise-induced metabolic responses, we have developed comprehensive plasma metabolite signatures by using mass spectrometry to measure >200 metabolites before and after exercise. We identified plasma indicators of glycogenolysis (glucose-6-phosphate), tricarboxylic acid cycle span 2 expansion (succinate, malate, and fumarate), and lipolysis (glycerol), as well as modulators of insulin sensitivity (niacinamide) and fatty acid oxidation (pantothenic acid). Metabolites that were highly correlated with fitness parameters were found in subjects undergoing acute exercise testing and marathon running and in 302 subjects from a longitudinal cohort study. Exercise-induced increases in glycerol were strongly related to fitness levels in normal individuals and were attenuated in subjects with myocardial ischemia. A combination of metabolites that increased in plasma in response to exercise (glycerol, niacinamide, glucose-6-phosphate, pantothenate, and succinate) up-regulated the expression of nur77, a transcriptional regulator of glucose utilization and lipid metabolism genes in skeletal muscle in vitro. Plasma metabolic profiles obtained during exercise provide signatures of exercise performance and cardiovascular disease susceptibility, in addition to highlighting molecular pathways that may modulate the salutary effects of exercise.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.