Trial reportInvestigative ophthalmology & visual science2010
Trichiasis surgery in The Gambia: a 4-year prospective study.
Trial report in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Systematic review of the incidence of post-operative trichiasis in Africa.BMC ophthalmology · 2020Pooled it
- Interventions for trachoma trichiasis.The Cochrane database of systematic reviews · 2015Pooled it
- The prevention and management of postoperative trachomatous trichiasis: A systematic review.Survey of ophthalmologyPooled it
- Baseline Predictors for the Postoperative Trachomatous Trichiasis Following Lid Rotation Surgery in the FLuorometholone as Adjunctive MEdical Therapy for Trachomatous Trichiasis Surgery (FLAME) Trial.Ophthalmic epidemiology · 2026Trial
- Oral doxycycline for the prevention of postoperative trachomatous trichiasis in Ethiopia: a randomised, double-blind, placebo-controlled trial.The Lancet. Global health · 2018Trial
- Posterior lamellar versus bilamellar tarsal rotation surgery for trachomatous trichiasis in Ethiopia: a randomised controlled trial.The Lancet. Global health · 2016Trial
- Epilation for minor trachomatous trichiasis: four-year results of a randomised controlled trial.PLoS neglected tropical diseases · 2015Trial
- Three-year outcomes of the surgery for trichiasis, antibiotics to prevent recurrence trial.Archives of ophthalmology (Chicago, Ill. : 1960) · 2012Trial
- Absorbable versus silk sutures for surgical treatment of trachomatous trichiasis in Ethiopia: a randomised controlled trial.PLoS medicine · 2011Trial
- Rates and risk factors for unfavorable outcomes 6 weeks after trichiasis surgery.Investigative ophthalmology & visual science · 2011Trial
- Article
- Article
- Understanding the spatial distribution of trichiasis and its association with trachomatous inflammation-follicular.BMC infectious diseases · 2019Article
- Lamellar Tarsectomy Procedure In Major Trichiasis Of The Upper Lid.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Comment on "Anterior lamellar recession for management of upper eyelid cicatricial entropion and associated eyelid abnormalities".International journal of ophthalmology · 2018Article
- Short term outcome of anterior lamellar reposition in treating trachomatous trichiasis.Journal of ophthalmology · 2015Article
- Follicular trachoma and trichiasis prevalence in an urban community in The Gambia, West Africa: is there a need to include urban areas in national trachoma surveillance?Tropical medicine & international health : TM & IH · 2013Article
- Will the SAFE strategy be sufficient to eliminate trachoma by 2020? Puzzlements and possible solutions.TheScientificWorldJournal · 2013Review
- The outcome of trachomatous trichiasis surgery in Ethiopia: risk factors for recurrence.PLoS neglected tropical diseases · 2013Article
- Post-operative recurrent trachomatous trichiasis is associated with increased conjunctival expression of S100A7 (psoriasin).PLoS neglected tropical diseases · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTrachoma is the leading infectious cause of blindness. Conjunctival Chlamydia trachomatis infection causes scarring, entropion, trichiasis, and blinding corneal opacification. Worldwide, there are 8 million people with trichiasis. Although trichiasis surgery can reduce the risk of blindness, retrospective data suggest that long-term recurrence rates may be high. A 4-year prospective investigation of recurrent trichiasis was conducted in The Gambia.
methodsPatients with trichiasis were examined at baseline, 6 months, 1 year, and 4 years after posterior lamellar tarsal rotation surgery. Conjunctival swabs for bacteriology and PCR for C. trachomatis were collected at baseline, 6 months, and 1 year.
resultsThree hundred fifty-six Gambian patients were enrolled at baseline and 266 were reassessed at 4 years (94% of surviving patients). The recurrence rates were 32%, 40%, and 41% at 6 months, 1 year, and 4 years, respectively. At 4 years, 30% of patients had bilateral trichiasis and 21% had bilateral corneal opacity. Recurrence was associated with severe conjunctival inflammation and severe trichiasis (>10 lashes) at baseline.
conclusionsTrichiasis recurrence rates were high, and most cases recurred within 6 months of surgery. The results suggest that there are important aspects of surgical technique and quality that should to be addressed. Persistent inflammation is strongly associated with recurrence at 4 years.
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