ArticleJournal of neurophysiology2010
Carbachol-induced long-term synaptic depression is enhanced during senescence at hippocampal CA3-CA1 synapses.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Development and validation of a predictive model for postoperative delirium in patients undergoing cardiac surgery.Frontiers in cardiovascular medicine · 2026Article
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- Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence.Neurochemical research · 2019Review
- Article
- Identification and Characterization of a G Protein-binding Cluster in α7 Nicotinic Acetylcholine Receptors.The Journal of biological chemistry · 2015Article
- Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.Hippocampus · 2014Article
- The cholinergic agonist carbachol increases the frequency of spontaneous GABAergic synaptic currents in dorsal raphe serotonergic neurons in the mouse.Neuroscience · 2014Article
- Presynaptic gating of postsynaptic synaptic plasticity: a plasticity filter in the adult auditory cortex.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2013Review
- Hippocampal Gαq/₁₁ but not Gαo-coupled receptors are altered in aging.Neuropharmacology · 2013Article
- Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor.Behavioural brain research · 2013Article
- Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology.Neurobiology of learning and memory · 2012Article
- Article
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Abstract
Dysregulation of the cholinergic transmitter system is a hallmark of Alzheimer's disease and contributes to an age-associated decline in memory performance. The current study examined the influence of carbachol, a cholinergic receptor agonist, on synaptic transmission over the course of aging. Extracellular excitatory postsynaptic field potentials were recorded from CA3-CA1 synapses in acute hippocampal slices obtained from young adult (5-8 mo) and aged (22-24 mo) male Fischer 344 rats. Bath application of carbachol elicited a transient depression of synaptic transmission, which was followed by a long-lasting depression (CCh-LTD) observed 90 min after carbachol cessation in both age groups. However, the magnitude of CCh-LTD was significantly larger in senescent animals and was attenuated by N-methyl-D-aspartate receptor blockade in aged animals. Blockade of L-type Ca(2+) channels inhibited CCh-LTD to a greater extent in aged animals compared to young adults. Finally, the expression of CCh-LTD was dependent on protein synthesis. The results indicate that altered Ca(2+) homeostasis or muscarinic activation of Ca(2+) signaling contribute to the enhanced CCh-LTD during senescence.
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