ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Dendritic calcium signaling in ON and OFF mouse retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Transient functional preservation precedes retinal ganglion cell degeneration following optic nerve crush.IBRO neuroscience reports · 2026Article
- Computational modelling of the suppression of optic nerve fibre.Medical & biological engineering & computing · 2026Article
- Article
- Review
- Membrane depolarization mediates both the inhibition of neural activity and cell-type-differences in response to high-frequency stimulation.Communications biology · 2024Article
- Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration.Life (Basel, Switzerland) · 2022Review
- Sensitivity to extracellular potassium underlies type-intrinsic differences in retinal ganglion cell excitability.Frontiers in cellular neuroscience · 2022Article
- Intrinsic Morphologic and Physiologic Development of Human Derived Retinal Ganglion Cells In Vitro.Translational vision science & technology · 2021Article
- Tailoring of the axon initial segment shapes the conversion of synaptic inputs into spiking output in OFF-α T retinal ganglion cells.Science advances · 2020Article
- Type-specific dendritic integration in mouse retinal ganglion cells.Nature communications · 2020Article
- TRPV1 Supports Axogenic Enhanced Excitability in Response to Neurodegenerative Stress.Frontiers in cellular neuroscience · 2020Article
- Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo.Light, science & applications · 2020Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Scaling of the AIS and Somatodendritic Compartments in α S RGCs.Frontiers in cellular neuroscience · 2019Article
- The Retinal Response to Sinusoidal Electrical Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2016Article
- GlyRα2, not GlyRα3, modulates the receptive field surround of OFF retinal ganglion cells.Visual neuroscience · 2015Article
- Immunohistochemical and calcium imaging methods in wholemount rat retina.Journal of visualized experiments : JoVE · 2014Article
- The effect of morphology upon electrophysiological responses of retinal ganglion cells: simulation results.Journal of computational neuroscience · 2014Article
- Selectivity of direct and network-mediated stimulation of the retinal ganglion cells with epi-, sub- and intraretinal electrodes.Journal of neural engineering · 2014Article
- Differential responses to high-frequency electrical stimulation in ON and OFF retinal ganglion cells.Journal of neural engineering · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Retinal ganglion cells (RGCs) are the output cells of the retina; they convert synaptic input into spike output that carries visual information to the brain. Synaptic inputs are received, integrated and communicated to the spike initiation zone of the axon by dendrites whose properties are poorly understood. Here simultaneous patch-clamp recording and 2-photon Ca(2+) imaging are used to study voltage- and light-evoked Ca(2+) signals in the dendrites of identified types of mouse RGCs from parallel ON and OFF pathways, which encode the onset and offset of light, respectively. The results show pathway-specific differences in voltage-dependent Ca(2+) signaling. While both ON and OFF cells express high-voltage-activated (HVA) Ca(2+) channels, only OFF RGCs also express low-voltage-activated (LVA) Ca(2+) channels. LVA Ca(2+) channels in OFF cells are deinactivated by hyperpolarization from the resting potential and give rise to rebound excited Ca(2+) spikes at the termination of a step of either hyperpolarizing current or light. This suggests that the differential expression of voltage-gated Ca(2+) channels in ON and OFF RGC dendrites contributes to differences in the way the two cell types process visual stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.