ArticleJournal of dental research2010
Biodegradation of resin-dentin interfaces increases bacterial microleakage.
Article in Journal of dental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed.
- Efficiency of desensitizing materials in xerostomic patients with head and neck cancer: a comparative clinical study.Clinical oral investigations · 2020Trial
- Microbial biofilm proliferation within sealer-root dentin interfaces is affected by sealer type and aging period.Journal of endodontics · 2012Trial
- Bonding Performance and Interfacial Ultra-Morphology/Nanoleakage of a Modern Self-Curing Bulk-Fill Restorative System: An In Vitro Study.European journal of dentistry · 2026Article
- Evaluation of a long-term antimicrobial dental adhesive via in vitro biodegradation and in vivo rodent secondary caries models.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Effect on hygroscopic characteristics of n-ZnO additions to resin composite.European journal of oral sciences · 2025Article
- Marginal and internal adaptation and absolute marginal discrepancy of 3D-printed, milled, and prefabricated crowns for primary molar teeth: an in vitro comparative study.BMC oral health · 2025Article
- Synergistic effects of bacteria, enzymes, and cyclic mechanical stresses on the bond strength of composite restorations.Biomaterials advances · 2025Article
- Natural Antibacterial Compounds with Potential for Incorporation into Dental Adhesives: A Systematic Review.Polymers · 2024Review
- Stoichiometric models of sucrose and glucose fermentation by oral streptococci: Implications for free acid formation and enamel demineralization.Dental materials : official publication of the Academy of Dental Materials · 2023Article
- Impact of curcumin loading on the physicochemical, mechanical and antimicrobial properties of a methacrylate-based experimental dental resin.Scientific reports · 2022Article
- Meta-analytical analysis on components released from resin-based dental materials.Clinical oral investigations · 2022Review
- Biodegradation of Dental Resin-Based Composite-A Potential Factor Affecting the Bonding Effect: A Narrative Review.Biomedicines · 2022Review
- A Study of Zn-Ca Nanocomposites and Their Antibacterial Properties.International journal of molecular sciences · 2022Article
- A novel methacrylate derivative polymer that resists bacterial cell-mediated biodegradation.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Interfacial Biomaterial-Dentin Bacterial Biofilm Proliferation and Viability Is Affected by the Material, Aging Media and Period.Dentistry journal · 2022Article
- Effect of staining on the mechanical, surface and biological properties of lithium disilicate.The Saudi dental journal · 2022Article
- Synthesis, characterization and evaluation of azobenzene nanogels for their antibacterial properties in adhesive dentistry.European journal of oral sciences · 2022Article
- Simulating the Intraoral Aging of Dental Bonding Agents: A Narrative Review.Dentistry journal · 2022Review
- Anti-Demineralization Effects of Dental Adhesive-Composites on Enamel-Root Dentin Junction.Polymers · 2021Article
- Cytotoxic and Genotoxic Effects of Composite Resins on Cultured Human Gingival Fibroblasts.Materials (Basel, Switzerland) · 2021Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Bis-GMA-containing resin composites and adhesives undergo biodegradation by human-saliva-derived esterases, yielding Bis-hydroxy-propoxy-phenyl-propane (Bis-HPPP). The hypothesis of this study is that the exposure of dental restorations to saliva-like esterase activities accelerates marginal bacterial microleakage. Resin composites (Scotchbond, Z250, 3M) bonded to human dentin were incubated in either buffer or dual-esterase media (pseudocholinesterase/cholesterol-esterase; PCE+CE), with activity levels simulating those of human saliva, for up to 90 days. Incubation solutions were analyzed for Bis-HPPP by high-performance liquid chromatography. Post-incubation, specimens were suspended in a chemostat-based biofilm fermentor cultivating Streptococcus mutans NG8, a primary species associated with dental caries, for 7 days. Bacterial microleakage was assessed by confocal laser scanning microscopy. Bis-HPPP production and depth and spatial volume of bacterial cell penetration within the interface increased with incubation time and were higher for 30- and 90-day PCE+CE vs. buffer-incubated groups, suggesting that biodegradation can contribute to the formation of recurrent decay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.