ArticleCold Spring Harbor perspectives in biology2010
Planetary organic chemistry and the origins of biomolecules.
Article in Cold Spring Harbor perspectives in biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 96 citations in OpenAlex.
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- Preferential formation of specific hexose and heptose in the formose reaction under microwave irradiation.RSC advances · 2023Article
- What makes a reaction network "chemical"?Journal of cheminformatics · 2022Article
- On the Origin of Sugar Handedness: Facts, Hypotheses and Missing Links-A Review.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2022Review
- Equilibrium and non-equilibrium furanose selection in the ribose isomerisation network.Nature communications · 2021Article
- Aldehyde catalysis - from simple aldehydes to artificial enzymes.RSC advances · 2020Review
- Extraterrestrial ribose and other sugars in primitive meteorites.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Hydroxymethanesulfonate from Volcanic Sulfur Dioxide: A "Mineral" Reservoir for Formaldehyde and Other Simple Carbohydrates in Prebiotic Chemistry.Astrobiology · 2019Article
- The Paleomineralogy of the Hadean Eon Revisited.Life (Basel, Switzerland) · 2018Review
- The Role of Templating in the Emergence of RNA from the Prebiotic Chemical Mixture.Life (Basel, Switzerland) · 2017Article
- On the Plausibility of Pseudosugar Formation in Cometary Ices and Oxygen-rich Tholins.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2016Article
- A hypothesis about the origin of biology.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2015Article
- Formaldehyde-a key monad of the biomolecular system.Life (Basel, Switzerland) · 2013Review
- Atmospheric Prebiotic Chemistry and Organic Hazes.Current organic chemistry · 2013Article
- Refining the genetic alphabet: a late-period selection pressure?Astrobiology · 2012Article
- On dating stages in prebiotic chemical evolution.Die Naturwissenschaften · 2012Article
- Is boron a prebiotic element? A mini-review of the essentiality of boron for the appearance of life on earth.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2012Review
- Sn-Beta zeolites with borate salts catalyse the epimerization of carbohydrates via an intramolecular carbon shift.Nature communications · 2012Article
- Energy flows, metabolism and translation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
- Serpentinite and the dawn of life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organic chemistry on a planetary scale is likely to have transformed carbon dioxide and reduced carbon species delivered to an accreting Earth. According to various models for the origin of life on Earth, biological molecules that jump-started Darwinian evolution arose via this planetary chemistry. The grandest of these models assumes that ribonucleic acid (RNA) arose prebiotically, together with components for compartments that held it and a primitive metabolism that nourished it. Unfortunately, it has been challenging to identify possible prebiotic chemistry that might have created RNA. Organic molecules, given energy, have a well-known propensity to form multiple products, sometimes referred to collectively as "tar" or "tholin." These mixtures appear to be unsuited to support Darwinian processes, and certainly have never been observed to spontaneously yield a homochiral genetic polymer. To date, proposed solutions to this challenge either involve too much direct human intervention to satisfy many in the community, or generate molecules that are unreactive "dead ends" under standard conditions of temperature and pressure. Carbohydrates, organic species having carbon, hydrogen, and oxygen atoms in a ratio of 1:2:1 and an aldehyde or ketone group, conspicuously embody this challenge. They are components of RNA and their reactivity can support both interesting spontaneous chemistry as part of a "carbohydrate world," but they also easily form mixtures, polymers and tars. We describe here the latest thoughts on how on this challenge, focusing on how it might be resolved using minerals containing borate, silicate, and molybdate, inter alia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.