Evidence map›Paper›PMID 20504938›Full record

ArticleJournal of virology2010

Trafficking of UL37 proteins into mitochondrion-associated membranes during permissive human cytomegalovirus infection.

Petros Bozidis, Chad D Williamson, Daniel S Wong, Anamaris M Colberg-Poley

Abstract read
In one paragraph

Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

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  13. Superresolution imaging of viral protein trafficking.Medical microbiology and immunology · 2015
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Petros BozidisCenter for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, Washington, DC 200101, USA.
Chad D Williamson
Daniel S Wong
Anamaris M Colberg-Poley
Children's National · USGeorge Washington University · US

Funding

HCMV UL37 Proteins: Trafficking &Functional DiversityR01AI057906 · NIAID · CHILDREN'S RESEARCH INSTITUTE · PI COLBERG POLEY, ANAMARIS MARTHA · 2005 to 2009
$1.5M
Alteration of ER:mitochondrial contacts by human cytomegalovirus infectionR21AI081957 · NIAID · CHILDREN'S RESEARCH INSTITUTE · PI COLBERG POLEY, ANAMARIS MARTHA · 2009 to 2010
$473k
NIAID NIH HHS R01 AI057906NIAID NIH HHS R21 AI081957
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) UL37 proteins traffic sequentially from the endoplasmic reticulum (ER) to the mitochondria. In transiently transfected cells, UL37 proteins traffic into the mitochondrion-associated membranes (MAM), the site of contact between the ER and mitochondria. In HCMV-infected cells, the predominant UL37 exon 1 protein, pUL37x1, trafficked into the ER, the MAM, and the mitochondria. Surprisingly, a component of the MAM calcium signaling junction complex, cytosolic Grp75, was increasingly enriched in heavy MAM from HCMV-infected cells. These studies show the first documented case of a herpesvirus protein, HCMV pUL37x1, trafficking into the MAM during permissive infection and HCMV-induced alteration of the MAM protein composition.

Indexed as

Cells, CulturedCytomegalovirus InfectionsEndoplasmic ReticulumFibroblastsHeLa CellsHSP70 Heat-Shock ProteinsHumansImmediate-Early ProteinsMembrane ProteinsMitochondrial MembranesProtein Transportglucose-regulated proteinsHSP70 Heat-Shock ProteinsImmediate-Early ProteinsMembrane ProteinsUL37 protein, Human herpesvirus 5

Identifiers

PMID20504938
PMCPMC2897597
OpenAlexW2040960916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.