ArticleBrain : a journal of neurology2010
Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions.
Article in Brain : a journal of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02501941 (Spreading Depolarization and Ketamine Suppression), which is not on this map. Cited by 105 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Spreading Depolarization and Ketamine Suppression
Who cites it
105 citing papers in PubMed, 3 syntheses or guidelines pooled it, 211 citations in OpenAlex.
- Genetic liability to migraine and functional outcome after ischemic stroke.European stroke journal · 2023Pooled it
- Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes-Where is the data: A systematic review.Frontiers in neurology · 2022Pooled it
- Systematic review of the pharmacological agents that have been tested against spreading depolarizations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Pooled it
- Initiation site of experimentally-evoked spreading depolarizations influence tissue outcomes in a murine stroke model.Experimental neurology · 2026Article
- Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques.GeroScience · 2026Review
- Quantitative Imaging of the Heterogeneity of Brain Potassium Depletion in Experimental Focal Ischemia.bioRxiv : the preprint server for biology · 2026Article
- Initiation site of experimentally-evoked spreading depolarizations influence tissue outcomes in a murine stroke model.bioRxiv : the preprint server for biology · 2025Article
- Article
- Reduced brain oxygen response to spreading depolarization predicts worse outcome in ischaemic stroke.Brain : a journal of neurology · 2025Observational
- Article
- Chronic Hyperhomocysteinemia Impairs CSD Propagation and Induces Cortical Damage in a Rat Model of Migraine with Aura.Biomolecules · 2024Article
- Interference with glutamate antiporter system xExperimental physiology · 2024Article
- Cerebral autoregulation, spreading depolarization, and implications for targeted therapy in brain injury and ischemia.Reviews in the neurosciences · 2024Review
- Ketamine-induced prevention of SD-associated late infarct progression in experimental ischemia.Scientific reports · 2024Article
- Ketamine improves neuronal recovery following spreading depolarization in peri-infarct tissues.Journal of neurochemistry · 2024Article
- High-density cortical µECoG arrays concurrently track spreading depolarizations and long-term evolution of stroke in awake rats.Communications biology · 2024Article
- Laser speckle imaging of the hippocampus.Biomedical optics express · 2024Article
- Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Role of Microglia in Stroke.Advances in neurobiology · 2024Review
- Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury.Science advances · 2023Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How does infarction in victims of stroke and other types of acute brain injury expand to its definitive size in subsequent days? Spontaneous depolarizations that repeatedly spread across the cerebral cortex, sometimes at remarkably regular intervals, occur in patients with all types of injury. Here, we show experimentally with in vivo real-time imaging that similar, spontaneous depolarizations cycle repeatedly around ischaemic lesions in the cerebral cortex, and enlarge the lesion in step with each cycle. This behaviour results in regular periodicity of depolarization when monitored at a single point in the lesion periphery. We present evidence from clinical monitoring to suggest that depolarizations may cycle in the ischaemic human brain, perhaps explaining progressive growth of infarction. Despite their apparent detrimental role in infarct growth, we argue that cycling of depolarizations around lesions might also initiate upregulation of the neurobiological responses involved in repair and remodelling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.