ArticleJournal of the Royal Society, Interface2010
Needle-shaped polymeric particles induce transient disruption of cell membranes.
Article in Journal of the Royal Society, Interface, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 91 citations in OpenAlex.
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- Synergistic Ferroptosis-Immunotherapy Nanoplatforms: Multidimensional Engineering for Tumor Microenvironment Remodeling and Therapeutic Optimization.Nano-micro letters · 2025Review
- Herbal Medicine Nanocrystals: A Potential Novel Therapeutic Strategy.Molecules (Basel, Switzerland) · 2023Review
- 3D DEM Simulations and Experiments on Spherical Impactor Penetrating into the Elongated Particles.Materials (Basel, Switzerland) · 2023Article
- Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials.Nanomaterials (Basel, Switzerland) · 2022Article
- 3D-Printing of Structure-Controlled Antigen Nanoparticles for Vaccine Delivery.Biomacromolecules · 2020Article
- Study of mitochondrial swelling, membrane fluidity and ROS production induced by nano-TiOToxicology research · 2019Article
- Shape dependent cytotoxicity of PLGA-PEG nanoparticles on human cells.Scientific reports · 2017Article
- The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation.Scientific reports · 2017Article
- Haemolytic activity of soil from areas of varying podoconiosis endemicity in Ethiopia.PloS one · 2017Article
- Nanocarriers for spleen targeting: anatomo-physiological considerations, formulation strategies and therapeutic potential.Drug delivery and translational research · 2016Review
- Efficient delivery of DNA into bovine preimplantation embryos by multiwall carbon nanotubes.Scientific reports · 2016Article
- Local viscoelasticity of living cells measured by rotational magnetic spectroscopy.Nature communications · 2016Article
- Phytochemicals and Biogenic Metallic Nanoparticles as Anticancer Agents.Oxidative medicine and cellular longevity · 2016Review
- Chemical basis of interactions between engineered nanoparticles and biological systems.Chemical reviews · 2014Review
- Natural mineral particles are cytotoxic to rainbow trout gill epithelial cells in vitro.PloS one · 2014Article
- Silicon micro- and nanofabrication for medicine.Advanced healthcare materials · 2013Review
- Article
- Higher lung accumulation of intravenously injected organic nanotubes.International journal of nanomedicine · 2013Article
- Hierarchically assembled theranostic nanostructures for siRNA delivery and imaging applications.Journal of the American Chemical Society · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Nano- and microparticles of various shapes have recently been introduced for various drug-delivery applications. Shape of particles has been shown to have an impact on various processes including circulation, vascular adhesion and phagocytosis. Here, we assess the role of particle geometry and surface chemistry in their interactions with cell membranes. Using representative particles of different shape (spheres, elongated and flat particles), size (500 nm-1 microm) and surface chemistry (positively and negatively charged), we evaluated the response of endothelial cells to particles. While spherical and elliptical disc-shaped particles did not have an impact on cell spreading and motility, needle-shaped particles induced significant changes in the same. Further studies revealed that needle-shaped particles induced disruption of cell membranes as indicated by the release of lactate dehydrogenase and uptake of extracellular calcein. The effect of needle-shaped particles on cells was transient and was reversed over a time period of 1-48 h depending on particle parameters.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.