ArticleJournal of the Royal Society, Interface2010
Relative brain displacement and deformation during constrained mild frontal head impact.
Article in Journal of the Royal Society, Interface, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 129 citations in OpenAlex.
- A novel spatiotemporal decomposition and identification of sparse equations for human brain deformation.Scientific reports · 2026Article
- Detection of transient tissue displacement using wavelet MR elastography: Phantom validation and in vivo human brain repeatability study.Magnetic resonance in medicine · 2025Article
- Experimental Assessment of Traction Force and Associated Fetal Brain Deformation in Vacuum-Assisted Delivery.Annals of biomedical engineering · 2025Article
- A Spatially Diverse 2TX-3RX Galvanic-Coupled Transdural Telemetry for Tether-Less Distributed Brain-Computer Interfaces.IEEE transactions on biomedical circuits and systems · 2024Article
- An Ultrasound-Powering TX with a Global Charge-Redistribution Adiabatic Drive Achieving 69% Power Reduction and 53° Maximum Beam Steering Angle for Implantable Applications.Digest of technical papers. IEEE International Solid-State Circuits Conference · 2024Article
- Magnetic Resonance Elastography-Based Technique to Assess the Biomechanics of the Skull-Brain Interface: Repeatability and Age-Sex Characteristics.Journal of neurotrauma · 2023Article
- Understanding Acquired Brain Injury: A Review.Biomedicines · 2022Review
- Galvanic-coupled Trans-dural Data Transfer for High-bandwidth Intra-cortical Neural Sensing.IEEE transactions on microwave theory and techniques · 2022Article
- Immediate induction of varicosities by transverse compression but not uniaxial stretch in axon mechanosensation.Acta neuropathologica communications · 2022Article
- A Finite Element Model of Cerebral Vascular Injury for Predicting Microbleeds Location.Frontiers in bioengineering and biotechnology · 2022Article
- MR Imaging of Human Brain Mechanics In Vivo: New Measurements to Facilitate the Development of Computational Models of Brain Injury.Annals of biomedical engineering · 2021Review
- Full-field MRI measurements of in-vivo positional brain shift reveal the significance of intra-cranial geometry and head orientation for stereotactic surgery.Scientific reports · 2021Article
- Natural oscillatory modes of 3D deformation of the human brain in vivo.Journal of biomechanics · 2021Article
- Smoothed particle hydrodynamic modelling of the cerebrospinal fluid for brain biomechanics: Accuracy and stability.International journal for numerical methods in biomedical engineering · 2021Article
- A machine learning approach for magnetic resonance image-based mouse brain modeling and fast computation in controlled cortical impact.Medical & biological engineering & computing · 2020Article
- In vivo estimates of axonal stretch and 3D brain deformation during mild head impact.Brain multiphysics · 2020Article
- Biomechanics of the Human Brain during Dynamic Rotation of the Head.Journal of neurotrauma · 2020Article
- Displacement- and Strain-Based Discrimination of Head Injury Models across a Wide Range of Blunt Conditions.Annals of biomedical engineering · 2020Article
- Quantitative Validation of MRI-Based Motion Estimation for Brain Impact Biomechanics.Computational biomechanics for medicine. Personalisation, validation and therapy · 2020Article
- 3-D Measurements of Acceleration-Induced Brain Deformation via Harmonic Phase Analysis and Finite-Element Models.IEEE transactions on bio-medical engineering · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
This study describes the measurement of fields of relative displacement between the brain and the skull in vivo by tagged magnetic resonance imaging and digital image analysis. Motion of the brain relative to the skull occurs during normal activity, but if the head undergoes high accelerations, the resulting large and rapid deformation of neuronal and axonal tissue can lead to long-term disability or death. Mathematical modelling and computer simulation of acceleration-induced traumatic brain injury promise to illuminate the mechanisms of axonal and neuronal pathology, but numerical studies require knowledge of boundary conditions at the brain-skull interface, material properties and experimental data for validation. The current study provides a dense set of displacement measurements in the human brain during mild frontal skull impact constrained to the sagittal plane. Although head motion is dominated by translation, these data show that the brain rotates relative to the skull. For these mild events, characterized by linear decelerations near 1.5g (g = 9.81 m s⁻²) and angular accelerations of 120-140 rad s⁻², relative brain-skull displacements of 2-3 mm are typical; regions of smaller displacements reflect the tethering effects of brain-skull connections. Strain fields exhibit significant areas with maximal principal strains of 5 per cent or greater. These displacement and strain fields illuminate the skull-brain boundary conditions, and can be used to validate simulations of brain biomechanics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.