ArticleTissue engineering. Part A2010
Colonization and osteogenic differentiation of different stem cell sources on electrospun nanofiber meshes.
Article in Tissue engineering. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Article
- Osteogenic differentiation of amniotic fluid mesenchymal stromal cells and their bone regeneration potential.World journal of stem cells · 2015Review
- A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone.Clinical & experimental metastasis · 2014Article
- Nanofiber orientation and surface functionalization modulate human mesenchymal stem cell behavior in vitro.Tissue engineering. Part A · 2014Article
- Mechanical properties of human amniotic fluid stem cells using nanoindentation.Journal of biomechanics · 2013Article
- Osteogenic differentiation of human placenta-derived mesenchymal stem cells (PMSCs) on electrospun nanofiber meshes.Cytotechnology · 2012Article
- Nanofiber-based delivery of bioactive agents and stem cells to bone sites.Advanced drug delivery reviews · 2012Review
- Effects of in vivo mechanical loading on large bone defect regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2012Article
- Cell sourcing for bone tissue engineering: amniotic fluid stem cells have a delayed, robust differentiation compared to mesenchymal stem cells.Stem cell research · 2011Article
- Tendon tissue engineering: adipose-derived stem cell and GDF-5 mediated regeneration using electrospun matrix systems.Biomedical materials (Bristol, England) · 2011Article
- An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects.Biomaterials · 2011Article
- Osteoinduction of human mesenchymal stem cells by bioactive composite scaffolds without supplemental osteogenic growth factors.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Numerous challenges remain in the successful clinical translation of cell-based therapies for musculoskeletal tissue repair, including the identification of an appropriate cell source and a viable cell delivery system. The aim of this study was to investigate the attachment, colonization, and osteogenic differentiation of two stem cell types, human mesenchymal stem cells (hMSCs) and human amniotic fluid stem (hAFS) cells, on electrospun nanofiber meshes. We demonstrate that nanofiber meshes are able to support these cell functions robustly, with both cell types demonstrating strong osteogenic potential. Differences in the kinetics of osteogenic differentiation were observed between hMSCs and hAFS cells, with the hAFS cells displaying a delayed alkaline phosphatase peak, but elevated mineral deposition, compared to hMSCs. We also compared the cell behavior on nanofiber meshes to that on tissue culture plastic, and observed that there is delayed initial attachment and proliferation on meshes, but enhanced mineralization at a later time point. Finally, cell-seeded nanofiber meshes were found to be effective in colonizing three-dimensional scaffolds in an in vitro system. This study provides support for the use of the nanofiber mesh as a model surface for cell culture in vitro, and a cell delivery vehicle for the repair of bone defects in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.