Evidence map›Paper›PMID 20504065›Full record

ReviewTissue engineering. Part B, Reviews2010

Stereolithographic bone scaffold design parameters: osteogenic differentiation and signal expression.

Kyobum Kim, Andrew Yeatts, David Dean, John P Fisher

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Tissue engineering. Part B, Reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 240 citations in OpenAlex.

  1. Pooled it
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  8. Bioprinted research models of urological malignancy.Exploration (Beijing, China) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kyobum KimDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, USA.
Andrew Yeatts
David Dean
John P Fisher
University of Maryland, College Park · USCase Western Reserve University · US

Funding

STRENGTH AND RESORPTION OF BIODEGRADABLE SKULL IMPLANTSR01DE013740 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI DEAN, DAVID · 2000 to 2011
$4.6M
NIDCR NIH HHS R01-DE013740
6 · The paper itself

Abstract

Scaffold design parameters including porosity, pore size, interconnectivity, and mechanical properties have a significant influence on osteogenic signal expression and differentiation. This review evaluates the influence of each of these parameters and then discusses the ability of stereolithography (SLA) to be used to tailor scaffold design to optimize these parameters. Scaffold porosity and pore size affect osteogenic cell signaling and ultimately in vivo bone tissue growth. Alternatively, scaffold interconnectivity has a great influence on in vivo bone growth but little work has been done to determine if interconnectivity causes changes in signaling levels. Osteogenic cell signaling could be also influenced by scaffold mechanical properties such as scaffold rigidity and dynamic relationships between the cells and their extracellular matrix. With knowledge of the effects of these parameters on cellular functions, an optimal tissue engineering scaffold can be designed, but a proper technology must exist to produce this design to specification in a repeatable manner. SLA has been shown to be capable of fabricating scaffolds with controlled architecture and micrometer-level resolution. Surgical implantation of these scaffolds is a promising clinical treatment for successful bone regeneration. By applying knowledge of how scaffold parameters influence osteogenic cell signaling to scaffold manufacturing using SLA, tissue engineers may move closer to creating the optimal tissue engineering scaffold.

Indexed as

Biocompatible MaterialsBone RegenerationCell DifferentiationTissue EngineeringAnimalsBone and BonesHumansSignal TransductionTissue ScaffoldsBiocompatible Materials

Identifiers

PMID20504065
PMCPMC2962858
OpenAlexW2097030798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.