ArticleThe Journal of comparative neurology2010
Light responses and morphology of bNOS-immunoreactive neurons in the mouse retina.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Nonlinear spatial integration allows the retina to detect the sign of defocus in natural scenes.Science advances · 2025Article
- The Healthy and Diseased Retina Seen through Neuron-Glia Interactions.International journal of molecular sciences · 2024Review
- The co-expression of the depolarizing and hyperpolarizing mechanosensitive ion channels in mammalian retinal neurons.Frontiers in medicine · 2024Article
- TRPV4 affects visual signals in photoreceptors and rod bipolar cells.Frontiers in cellular neuroscience · 2024Article
- Modulation of narrow-field amacrine cells on light-evoked spike responses and receptive fields of retinal ganglion cells.Vision research · 2023Article
- Article
- Oxidative and Nitrosative Stress in Age-Related Macular Degeneration: A Review of Their Role in Different Stages of Disease.Antioxidants (Basel, Switzerland) · 2021Review
- Amacrine Cells Forming Gap Junctions With Intrinsically Photosensitive Retinal Ganglion Cells: ipRGC Types, Neuromodulator Contents, and Connexin Isoform.Investigative ophthalmology & visual science · 2021Article
- Roles of the ocular pressure, pressure-sensitive ion channel, and elasticity in pressure-induced retinal diseases.Neural regeneration research · 2021Article
- Dual-Cell Patch-Clamp Recording Revealed a Mechanism for a Ribbon Synapse to Process Both Digital and Analog Inputs and Outputs.Frontiers in cellular neuroscience · 2021Article
- Ocular Pressure-Volume Relationship and Ganglion Cell Death in Glaucoma.OBM neurobiology · 2021Article
- Mouse Retinal Cell Atlas: Molecular Identification of over Sixty Amacrine Cell Types.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Nitrosative Stress in Retinal Pathologies: Review.Antioxidants (Basel, Switzerland) · 2019Review
- The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells.Cell death & disease · 2019Article
- Distribution and diversity of intrinsically photosensitive retinal ganglion cells in tree shrew.The Journal of comparative neurology · 2019Article
- A Self-Regulating Gap Junction Network of Amacrine Cells Controls Nitric Oxide Release in the Retina.Neuron · 2018Article
- Cone synapses in mammalian retinal rod bipolar cells.The Journal of comparative neurology · 2018Article
- Lhx9 Is Required for the Development of Retinal Nitric Oxide-Synthesizing Amacrine Cell Subtype.Molecular neurobiology · 2018Article
- Nitric oxide promotes GABA release by activating a voltage-independent CaJournal of neurophysiology · 2017Article
- Electrophysiological fingerprints of OFF bipolar cells in rat retina.Scientific reports · 2016Article
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3 authors.
Funding
Abstract
Nitric oxide (NO), produced by NO synthase (NOS), modulates the function of all retinal neurons and ocular blood vessels and participates in the pathogenesis of ocular diseases. To further understand the regulation of ocular NO release, we systematically studied the morphology, topography, and light responses of NOS-containing amacrine cells (NOACs) in dark-adapted mouse retina. Immunohistological staining for neuronal NOS (bNOS), combined with retrograde labeling of ganglion cells (GCs) with Neurobiotin (NB, a gap junction permeable dye) and Lucifer yellow (LY, a less permeable dye), was used to identify NOACs. The light responses of ACs were recorded under whole-cell voltage clamp conditions and cell morphology was examined with a confocal microscope. We found that in dark-adapted conditions bNOS-immunoreactivity (IR) was present primarily in the inner nuclear layer and the ganglion cell layer. bNOS-IR somas were negative for LY, thus they were identified as ACs; nearly 6% of the cells were labeled by NB but not by LY, indicating that they were dye-coupled with GCs. Three morphological subtypes of NOACs (NI, NII, and displaced) were identified. The cell density, intercellular distance, and the distribution of NOACs were studied in whole retinas. Light evoked depolarizing highly sensitive ON-OFF responses in NI cells and less sensitive OFF responses in NII cells. Frequent (1-2 Hz) or abrupt change of light intensity evoked larger peak responses. The possibility for light to modify NO release from NOACs is discussed.
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