ArticleThe Journal of comparative neurology2010
Neonatal androgen-dependent sex differences in lumbar spinal cord dopamine concentrations and the number of A11 diencephalospinal dopamine neurons.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Activation of mu-opioid receptors slows pacemaking in hypothalamic A11 dopamine neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Sex-related differences in motoneuron firing behavior during typical development.Journal of neurophysiology · 2025Article
- Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPREMBO reports · 2023Article
- Sex differences in the central regulation of colorectal motility in response to noxious stimuli.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2023Article
- Calbindin-Positive Neurons Co-express Functional Markers in a Location-Dependent Manner Within the A11 Region of the Rat Brain.Neurochemical research · 2021Article
- Dopaminergic Modulation of Orofacial Mechanical Hypersensitivity Induced by Infraorbital Nerve Injury.International journal of molecular sciences · 2020Article
- Gestational Exposure to Sodium Valproate Disrupts Fasciculation of the Mesotelencephalic Dopaminergic Tract, With a Selective Reduction of Dopaminergic Output From the Ventral Tegmental Area.Frontiers in neuroanatomy · 2020Article
- Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Optogenetic Activation of A11 Region Increases Motor Activity.Frontiers in neural circuits · 2018Article
- Three Types of A11 Neurons Project to the Rat Spinal Cord.Neurochemical research · 2017Article
- Catecholaminergic connectivity to the inner ear, central auditory, and vocal motor circuitry in the plainfin midshipman fish porichthys notatus.The Journal of comparative neurology · 2014Article
- Dopamine: a parallel pathway for the modulation of spinal locomotor networks.Frontiers in neural circuits · 2014Review
- Article
- Bilateral descending hypothalamic projections to the spinal trigeminal nucleus caudalis in rats.PloS one · 2013Article
- Opioid-mediated regulation of A11 diencephalospinal dopamine neurons: pharmacological evidence of activation by morphine.Neuropharmacology · 2011Article
- Estrogenic regulation of dopaminergic neurons in the opportunistically breeding zebra finch.General and comparative endocrinology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
A(11) diencephalospinal dopamine (DA) neurons provide the major source of DA innervation to the spinal cord. DA in the dorsal and ventral horns modulates sensory, motor, nociceptive, and sexual functions. Previous studies from our laboratory revealed a sex difference in the density of DA innervation in the lumbar spinal cord. The purpose of this study was to determine whether sex differences in spinal cord DA are androgen dependent, influenced by adult or perinatal androgens, and whether a sex difference in the number of lumbar-projecting A(11) neurons exists. Adult male mice have significantly higher DA concentrations in the lumbar spinal cord than either females or males carrying the testicular feminization mutation (tfm) in the androgen receptor (AR) gene, suggesting an AR-dependent origin. Spinal cord DA concentrations are not changed following orchidectomy in adult male mice or testosterone administration to ovariectomized adult female mice. Administration of exogenous testosterone to postnatal day 2 female mice results in DA concentrations in the adult lumbar spinal cord comparable to those of males. Male mice display significantly more lumbar-projecting A(11) DA neurons than females, particularly in the caudal portion of the A(11) cell body region, as determined by retrograde tract tracing and immunohistochemistry directed toward tyrosine hydroxylase. These results reveal an AR-dependent sex difference in both the number of lumbar-projecting A(11) DA neurons and the lumbar spinal cord DA concentrations, organized by the presence of androgens early in life. The AR-dependent sex difference suggests that this system serves a sexually dimorphic function in the lumbar spinal cord.
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Registered trials
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