ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Identification of germ plasm-associated transcripts by microarray analysis of Xenopus vegetal cortex RNA.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Subcellularly Resolved 3D Translatome in Mouse Oocytes and Early Embryos.bioRxiv : the preprint server for biology · 2026Article
- Primordial Germ Cell Specification in Vertebrate Embryos: Phylogenetic Distribution and Conserved Molecular Features of Preformation and Induction.Frontiers in cell and developmental biology · 2021Review
- Early Xenopus gene regulatory programs, chromatin states, and the role of maternal transcription factors.Current topics in developmental biology · 2020Review
- Asymmetric distribution of biomolecules of maternal origin in the Xenopus laevis egg and their impact on the developmental plan.Scientific reports · 2018Article
- EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation.Nature cell biology · 2018Article
- Selection of mitochondria in female germline cells: is Balbiani body implicated in this process?Journal of assisted reproduction and genetics · 2017Review
- Article
- High-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration.Development (Cambridge, England) · 2017Article
- Maternal messages to live by: a personal historical perspective.Genesis (New York, N.Y. : 2000) · 2017Review
- Article
- Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.Genesis (New York, N.Y. : 2000) · 2016Article
- High-Sensitivity Mass Spectrometry for Probing Gene Translation in Single Embryonic Cells in the Early Frog (Frontiers in cell and developmental biology · 2016Article
- Molecular asymmetry in the 8-cell stage Xenopus tropicalis embryo described by single blastomere transcript sequencing.Developmental biology · 2015Article
- Global analysis of asymmetric RNA enrichment in oocytes reveals low conservation between closely related Xenopus species.Molecular biology of the cell · 2015Article
- Intracellular microRNA profiles form in the Xenopus laevis oocyte that may contribute to asymmetric cell division.Scientific reports · 2015Article
- Regulation of neurogenesis by Fgf8a requires Cdc42 signaling and a novel Cdc42 effector protein.Developmental biology · 2013Article
- DEADSouth protein localizes to germ plasm and is required for the development of primordial germ cells in Xenopus laevis.Biology open · 2013Article
- Single blastomere expression profiling of Xenopus laevis embryos of 8 to 32-cells reveals developmental asymmetry.Scientific reports · 2013Article
- The role of DNA exonucleases in protecting genome stability and their impact on ageing.Age (Dordrecht, Netherlands) · 2012Review
- Principles and roles of mRNA localization in animal development.Development (Cambridge, England) · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
RNA localization is a common mechanism for regulating cell structure and function. Localized RNAs in Xenopus oocytes are critical for early development, including germline specification by the germ plasm. Despite the importance of these localized RNAs, only approximately 25 have been identified and fewer are functionally characterized. Using microarrays, we identified a large set of localized RNAs from the vegetal cortex. Overall, our results indicate a minimum of 275 localized RNAs in oocytes, or 2-3% of maternal transcripts, which are in general agreement with previous findings. We further validated vegetal localization for 24 candidates and further characterized three genes expressed in the germ plasm. We identified novel germ plasm expression for reticulon 3.1, exd2 (a novel exonuclease-domain encoding gene), and a putative noncoding RNA. Further analysis of these and other localized RNAs will likely identify new functions of germ plasm and facilitate the identification of cis-acting RNA localization elements.
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