ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal organ at Single Cell Resolution.bioRxiv : the preprint server for biology · 2024Article
- Identity, lineage and fates of a temporally distinct progenitor population in the embryonic olfactory epithelium.Developmental biology · 2023Article
- Functional analysis of sense organ specification in the Tribolium castaneum larva reveals divergent mechanisms in insects.BMC biology · 2021Article
- Why Does the Face Predict the Brain? Neural Crest Induction, Craniofacial Morphogenesis, and Neural Circuit Development.Frontiers in physiology · 2020Review
- The strengths of the genetic approach to understanding neural systems development and function: Ray Guillery's synthesis.The European journal of neuroscience · 2019Review
- Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells.Stem cell reports · 2016Article
- Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure.Developmental cell · 2015Article
- GnRH, anosmia and hypogonadotropic hypogonadism--where are we?Frontiers in neuroendocrinology · 2015Review
- Transcriptional regulation of cranial sensory placode development.Current topics in developmental biology · 2015Review
- Neural crest and olfactory system: new prospective.Molecular neurobiology · 2012Review
- Specification of GnRH-1 neurons by antagonistic FGF and retinoic acid signaling.Developmental biology · 2012Article
- Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in schizophrenia.Behavioral neuroscience · 2012Article
- The generation of olfactory epithelial neurospheres in vitro predicts engraftment capacity following transplantation in vivo.Experimental neurology · 2011Article
- Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium.Development (Cambridge, England) · 2010Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
We asked whether specific mesenchymal/epithelial (M/E) induction generates olfactory receptor neurons (ORNs), vomeronasal neurons (VRNs), and gonadotropin-releasing hormone (GnRH) neurons, the major neuron classes associated with the olfactory epithelium (OE). To assess specificity of M/E-mediated neurogenesis, we compared the influence of frontonasal mesenchyme on frontonasal epithelium, which becomes the OE, with that of the forelimb bud. Despite differences in position, morphogenetic and cytogenic capacity, both mesenchymal tissues support neurogenesis, expression of several signaling molecules and neurogenic transcription factors in the frontonasal epithelium. Only frontonasal mesenchyme, however, supports OE-specific patterning and activity of a subset of signals and factors associated with OE differentiation. Moreover, only appropriate pairing of frontonasal epithelial and mesenchymal partners yields ORNs, VRNs, and GnRH neurons. Accordingly, the position and molecular identity of specialized frontonasal epithelia and mesenchyme early in gestation and subsequent inductive interactions specify the genesis and differentiation of peripheral chemosensory and neuroendocrine neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.