ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation.Development (Cambridge, England) · 2026Article
- Foxm1 promotes differentiation of neural progenitors in the zebrafish inner ear.Developmental biology · 2025Article
- Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation.Cell communication and signaling : CCS · 2025Article
- Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart.Stem cell reports · 2023Article
- Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development.Developmental biology · 2023Article
- Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear.Developmental biology · 2022Article
- Manzamine-A Alters In Vitro Calvarial Osteoblast Function.Marine drugs · 2022Article
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- Genetics and signaling mechanisms of orofacial clefts.Birth defects research · 2020Review
- Building the Border: Development of the Chordate Neural Plate Border Region and Its Derivatives.Frontiers in physiology · 2020Review
- Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9.EBioMedicine · 2019Article
- Enriched Differentiation of Human Otic Sensory Progenitor Cells Derived From Induced Pluripotent Stem Cells.Frontiers in molecular neuroscience · 2018Article
- Expression, function, and regulation of the embryonic transcription factor TBX1 in parathyroid tumors.Laboratory investigation; a journal of technical methods and pathology · 2017Article
- Article
- MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells.Disease models & mechanisms · 2015Article
- Making sense of Wnt signaling-linking hair cell regeneration to development.Frontiers in cellular neuroscience · 2015Review
- Segregating neural and mechanosensory fates in the developing ear: patterning, signaling, and transcriptional control.Cell and tissue research · 2015Review
- Signaling mechanisms controlling cranial placode neurogenesis and delamination.Developmental biology · 2014Review
- A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea.Development (Cambridge, England) · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To understand the mechanism by which canonical Wnt signaling sets boundaries for pattern formation in the otic vesicle (OV), we examined Tbx1 and Eya1-Six1 downstream of activated beta-catenin. Tbx1, the gene for velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS), is essential for inner ear development where it promotes Bmp4 and Otx1 expression and restricts neurogenesis. Using floxed beta-catenin gain-of-function (GOF) and loss-of-function (LOF) alleles, we found Tbx1 expression was down-regulated and maintained/enhanced in the two mouse mutants, respectively. Bmp4 was ectopically expressed and Otx1 was lost in beta-catenin GOF mutants. Normally, inactivation of Tbx1 causes expanded neurogenesis, but expression of NeuroD was down-regulated in beta-catenin GOF mutants. To explain this paradox, Eya1 and Six1, genes for branchio-oto-renal (BOR) syndrome were down-regulated in the OV of beta-catenin GOF mutants independently of Tbx1. Overall, this work helps explain the mechanism by which Wnt signaling modulates transcription factors required for neurogenesis and patterning of the OV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.