ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Distinct transcriptional programs define cranial motor neuron subtypes during vertebrate development.bioRxiv : the preprint server for biology · 2026Article
- Development and migration of the zebrafish rhombencephalic octavolateral efferent neurons.The Journal of comparative neurology · 2021Article
- Defective Neuronal Positioning Correlates With Aberrant Motor Circuit Function in Zebrafish.Frontiers in neural circuits · 2021Article
- Rapid image deconvolution and multiview fusion for optical microscopy.Nature biotechnology · 2020Article
- Prickle1 is required for EMT and migration of zebrafish cranial neural crest.Developmental biology · 2019Article
- Robo1 and 2 Repellent Receptors Cooperate to Guide Facial Neuron Cell Migration and Axon Projections in the Embryonic Mouse Hindbrain.Neuroscience · 2019Article
- Talking back: Development of the olivocochlear efferent system.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Role of branchiomotor neurons in controlling food intake of zebrafish larvae.Journal of neurogenetics · 2017Article
- A role for planar cell polarity during early endoderm morphogenesis.Biology open · 2017Article
- Planar cell polarity in moving cells: think globally, act locally.Development (Cambridge, England) · 2017Review
- The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice.Developmental biology · 2016Article
- PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration.PLoS genetics · 2016Article
- Cadherin-2 Is Required Cell Autonomously for Collective Migration of Facial Branchiomotor Neurons.PloS one · 2016Article
- Rest represses maturation within migrating facial branchiomotor neurons.Developmental biology · 2015Article
- Prickle1 is necessary for the caudal migration of murine facial branchiomotor neurons.Cell and tissue research · 2014Article
- Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms.Developmental biology · 2014Article
- Mouse hindbrain ex vivo culture to study facial branchiomotor neuron migration.Journal of visualized experiments : JoVE · 2014Article
- Structural and temporal requirements of Wnt/PCP protein Vangl2 function for convergence and extension movements and facial branchiomotor neuron migration in zebrafish.Mechanisms of development · 2014Article
- The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function.Developmental biology · 2013Article
- Shaping the nervous system: role of the core planar cell polarity genes.Nature reviews. Neuroscience · 2013Review
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4 authors.
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Abstract
The facial branchiomotor neurons undergo a characteristic tangential migration in the vertebrate hindbrain. Several signaling mechanisms have been implicated in this process, including the non-canonical Wnt/planar cell polarity (PCP) pathway. However, the role of this signaling pathway in controlling the dynamics of these neurons is unclear. Here, we describe the cellular dynamics of the facial neurons as they migrate, focusing on the speed and direction of migration, extension of protrusions, cell shape, and orientation. Furthermore, we show that the PET/LIM domain protein Prickle1b (Pk1b) is required for several aspects of these migratory behaviors, including cell orientation. However, we find that centrosome localization is not significantly affected by disruption of Pk1b function, suggesting that polarization of the neurons is not completely lost. Together, our data suggest that Pk1b function may be required to integrate the multiple migratory cues received by the neurons into polarization instructions for proper posterior movement.
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