ArticlePediatric pulmonology2010
Viruses and atypical bacteria associated with asthma exacerbations in hospitalized children.
Article in Pediatric pulmonology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Prevalence of respiratory viruses in stable and acute asthma: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- miR-122 promotes virus-induced lung disease by targeting SOCS1.JCI insight · 2021Trial
- Virological Profile of Asthma Exacerbation in Children: A Hospital-Based Retrospective Study.Cureus · 2024Article
- [Detection of respiratory pathogens and clinical features in 225 children with acute exacerbation of bronchial asthma].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Antibodies against atypical pathogens and respiratory viruses detected by Pneumoslide IgM test in adults with community-acquired pneumonia in Guangzhou City.Journal of clinical laboratory analysis · 2020Article
- Respiratory pathogens and clinical outcomes in children with an asthma exacerbation: A systematic review.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2019Review
- Correlation between chest radiographic findings and clinical features in hospitalized children with Mycoplasma pneumoniae pneumonia.PloS one · 2019Article
- Asthma exacerbations in a subtropical area and the role of respiratory viruses: a cross-sectional study.BMC pulmonary medicine · 2018Article
- Nasopharyngeal isolates and their clinical impact on young children with asthma: a pilot study.Journal of asthma and allergy · 2018Article
- Detection of pathogens by real-time PCR in adult patients with acute exacerbation of bronchial asthma.BMC pulmonary medicine · 2017Article
- Mycoplasma pneumoniae from the Respiratory Tract and Beyond.Clinical microbiology reviews · 2017Review
- Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma.BMC microbiology · 2017Article
- [Value of routine identification of respiratory infectious agents in children hospitalized with an acute asthma exacerbation].Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2014Article
- Mycoplasma pneumoniae in children with acute and refractory asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013Article
- Asthma-associated differences in microbial composition of induced sputum.The Journal of allergy and clinical immunology · 2013Article
- Immune responses to self-antigens in asthma patients: clinical and immunopathological implications.Human immunology · 2012Article
- The infectious march: the complex interaction between microbes and the immune system in asthma.Immunology and allergy clinics of North America · 2010Review
- Exacerbation of asthma and airway infection: is the virus the villain?Jornal de pediatriaReview
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledOBJECTIVES AND WORKING HYPOTHESIS: To evaluate the prevalence of respiratory viruses Mycoplasma pneumoniae and Chlamydophila pneumoniae and gain insight into their seasonal circulation pattern in children with acute asthma exacerbations in a temperate southern hemisphere region. STUDY
designPatients hospitalized between 3 months and 16 years of age were included in a 1-year prospective, observational, cross-sectional study. Respiratory secretions were collected and the presence of different viruses and atypical bacteria analyzed by immunofluorescence and polymerase chain reaction.
resultsTwo hundred nine patients (118 females) aged (mean +/- SD) 4.4 +/- 4 years were included. A potential causative agent was detected in 78% of the patients. The most frequently detected viruses were respiratory syncytial virus (HRSV) (n = 85; 40%) and rhinovirus (HRV) (n = 52; 24.5%); M. pneumoniae and C. pneumoniae were detected in 4.5% and 2% of the cases, respectively. Patients with HRSV (vs. HRV) were hospitalized for a longer time (6.7 vs. 5.2 days, P = 0.012), required more days of oxygen supply (5.1 vs. 3.4, P = 0.005), had a longer duration of the exacerbation before hospitalization (3.6 vs. 1.9 days, P = 0.001) and were younger (3.7 vs. 5.1 years, P = 0.012). Three peaks of admissions were observed. A first peak (early autumn) caused by HRV, a second peak (winter) caused mainly by HRSV and a third one (spring), caused by HRSV, an increase in HMPV together with a second outbreak of HRV.
conclusionsChildren with an acute asthma exacerbation presented a high prevalence of respiratory viruses. Most hospitalizations corresponded to seasonal increases in prevalence of HRV and HRSV.
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