ArticlePediatric pulmonology2010
Pulmonary exacerbations in cystic fibrosis with negative bacterial cultures.
Article in Pediatric pulmonology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Vaping-Dependent Pulmonary Inflammation Is CaInternational journal of molecular sciences · 2024Article
- Impact of Antibiotics on the Lung Microbiome and Lung Function in Children With Cystic Fibrosis 1 Year After Hospitalization for an Initial Pulmonary Exacerbation.Open forum infectious diseases · 2022Article
- Pro con debates in clinical medicine infection prevention and control in cystic fibrosis: One size fits all? The argument in favour.Paediatric respiratory reviews · 2020Review
- MiRNA Expression Profile in the Airways is Altered during Pulmonary Exacerbation in Children with Cystic Fibrosis-A Preliminary Report.Journal of clinical medicine · 2020Article
- Article
- Cystic fibrosis respiratory microbiota: unraveling complexity to inform clinical practice.Expert review of respiratory medicine · 2018Review
- Changes in the lung bacteriome in relation to antipseudomonal therapy in children with cystic fibrosis.Folia microbiologica · 2018Article
- Volatile molecules from bronchoalveolar lavage fluid can 'rule-in' Pseudomonas aeruginosa and 'rule-out' Staphylococcus aureus infections in cystic fibrosis patients.Scientific reports · 2018Article
- Molecular Elucidation of Disease Biomarkers at the Interface of Chemistry and Biology.Journal of the American Chemical Society · 2017Article
- Article
- Association Between Outcomes and Demographic Factors in an Azeri Turkish Population With Cystic Fibrosis: A Cross-Sectional Study in Iran From 2001 Through 2014.Iranian Red Crescent medical journal · 2016Article
- Airway Microbiota in Bronchoalveolar Lavage Fluid from Clinically Well Infants with Cystic Fibrosis.PloS one · 2016Article
- One Center's Guide to Outpatient Management of Pediatric Cystic Fibrosis Acute Pulmonary Exacerbation.Clinical medicine insights. Pediatrics · 2016Article
- Ability of device to collect bacteria from cough aerosols generated by adults with cystic fibrosis.F1000Research · 2016Article
- Nontuberculous Mycobacteria in Cystic Fibrosis.Current treatment options in infectious diseases · 2016Review
- The pediatric microbiome and the lung.Current opinion in pediatrics · 2015Review
- Directly sampling the lung of a young child with cystic fibrosis reveals diverse microbiota.Annals of the American Thoracic Society · 2014Review
- Treatment of pulmonary exacerbations in cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2013Review
- Molecular detection of CF lung pathogens: current status and future potential.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2013Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPulmonary exacerbations are a major cause of morbidity in cystic fibrosis (CF) and likely contribute to lung function decline. Exacerbations are often associated with characteristic airway bacteria [CF related bacteria (CFRB)]. However, some patients do not have CFRB detected by culture during exacerbations.
objectivesWe sought to determine the proportion of airway cultures negative for CFRB during pulmonary exacerbations, and to characterize patients who were CFRB-negative versus CFRB-positive.
methodsWe performed a retrospective study of patients with CF admitted for a pulmonary exacerbation. Patients were classified as CFRB-positive or CFRB-negative based on admission airway cultures. Demographics, clinical presentation, lung function, history of chronic Pseudomonas aeruginosa infection and improvement in lung function with treatment were compared between groups. MAIN
resultsThere were 672 admissions for exacerbation involving 211 patients over 5 years. Seventeen percent were classified as CFRB-negative. Forty-one percent of bronchoalveolar lavage (BAL), 32% of throat and 10% of sputum samples were CFRB-negative. Among patients capable of expectorating sputum, the CFRB-negative group was younger, less likely to have chronic P. aeruginosa, had higher lung function and body mass index (BMI), and had a lower systemic inflammatory response on admission compared to those with CFRB-positive cultures. The two groups had similar numbers of patients with three or more signs and symptoms of a pulmonary exacerbation (88% vs. 92%). Both groups returned to baseline lung function following treatment.
conclusionsA significant number of patients with CF and pulmonary exacerbation did not have typical CFRB detected by culture. Patients without CFRB still had characteristic signs and symptoms of pulmonary exacerbation and responded to treatment. Understanding the causes of illness in these patients may improve the diagnosis and treatment of pulmonary exacerbations in CF.
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